Search for dissertations about: "lithocholic acid"
Found 5 swedish dissertations containing the words lithocholic acid.
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1. Hydrophobic interactions of serpins
Abstract : The proteins of the serpin family are primarily but not exclusively proteinase inhibitors, which share a common, similar structure. It is known that this structure undergoes major conformational changes upon cleavage in the serpin reactive site loop, and that these changes include rearrangements within the hydrophobic core of the molecule. READ MORE
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2. On the regulation of hepatic cholesterol and bile acid metabolism in gallstone patients
Abstract : The liver plays an important role in the regulation of cholesterol homeostasis, therefore also in the pathogenesis of arteriosclerosis and gallstone disease. The quantitatively most important way by which cholesterol is removed from the human body is via the bile, either as free cholesterol or after transformation to bile acids. READ MORE
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3. Cytochrome P450 enzymes in the biosynthesis and metabolism of bile acids and active forms of vitamin D
Abstract : Cytochrome P450 enzymes catalyzing hydroxylations in the biosynthesis and metabolism of bile acids and active forms of vitamin D3 were studied.A microsomal cytochrome P450 enzyme with a molecular mass of 53 kDa, catalyzing the 6α-hydroxylation of taurochenodeoxycholic acid was purfied from pig liver microsomes and characterized with respect to catalytic and electrophoretic properties as well as polyclonal antibodies. READ MORE
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4. Inflammatory bowel disease : determinants related to gut microbiota
Abstract : Inflammatory bowel disease (IBD) is a chronic and idiopathic disorder that causes inflammation in the gastrointestinal tract. Overall, it can be classified into two types: ulcerative colitis (UC) and Crohn's disease (CD). READ MORE
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5. Toxicological aspects of bile acids and human fecal water on cultured human colon carcinoma cells
Abstract : Colorectal tumorigenesis involves activation of mutations in proto-oncogenes, such as ras and c-myc, as well as mutations that inactivate tumor suppressor genes including the APC and the p53 gene. These genetic events, in turn, lead to epigenetic changes in signal transduction pathways, which regulate processes such as cell proliferation, differentiation and apoptosis. READ MORE