Search for dissertations about: "local drug delivery systems"

Showing result 1 - 5 of 18 swedish dissertations containing the words local drug delivery systems.

2. 1. Biopharmaceutical Evaluation of Intra-arterial Drug-Delivery Systems for Liver Cancer : Investigations in healthy pigs and liver cancer patients

   Author : Elsa Lilienberg; Hans Lennernäs; Erik Sjögren; Niklas Axén; Helen M. Burt; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vivo release; drug delivery systems; local delivery; drug disposition; doxorubicin; hepatocellular carcinoma; transarterial chemoembolization; transarterial chemotherapy infusion; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : There are currently two types of intra-arterial drug-delivery system (DDS) in clinical use in the palliative treatment of primary liver cancer. The chemotherapeutic drug doxorubicin (DOX) can be formulated into a drug-in-lipiodol emulsion (LIPDOX) or a microparticulate drug-eluting bead system (DEBDOX). READ MORE

4. 2. On enhancement of bone formation using local drug delivery systems

   Author : Ali Alenezi; Ann Wennerberg; Malmö universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone formation; local drug delivery systems;

   Abstract : Introduction: Despite that many reports have confirmed the long-term clinical success rates associated with implant treatment, implant failure to achieve and maintain osseointegration still occurs in many cases. Local and sustained drug release at the bone-implant interface is one of the strategies that have been suggested to improve the osseointegration. READ MORE

5. 3. Nanoparticle-based drug delivery systems for neural interfaces - a novel approach for improved biocompatibility

   Author : Alexander Dontsios Holmkvist; Neurofysiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Neural interfaces; brain damage injury; Minocycline; Gelatin; Nanoparticles; Drug-delivery systems; Biocompatibility; Tissue responses; immunohistochemistry IHC ; Poly D; L-lactic-co-glycolic acid PLGA ; Hydrophobic ion paring; Emulsification-solvent-diffusion method; Drug release; Microglia activation;

   Abstract : The overall purpose of this thesis was to reduce brain tissue responses around implanted microelectrodes using a pharmacological strategy. One of the main aims was to develop and evaluate drug delivery systems that allow local administration of anti-inflammatory pharmaceutics. READ MORE

6. 4. Effects of Microparticulate Drug Delivery Systems : Tissue Responses and Transcellular Transport

   Author : Eva Ragnarsson; Per Artursson; Lucia Lazorova; David Brayden; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; microparticles; vaccine; pDNA vaccine; cationic polymer; gene expression analysis DNA array ; Caco-2; follicle-associated epithelium FAE ; M cell; transcytosis; Yersinia pseudotuberculosis; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Abstract : Over the past decade, the development of macromolecular drugs based on peptides, proteins and nucleic acids has increased the interest in microparticulate drug delivery, i.e., the delivery of drug systems in the nanometer and micrometer ranges. READ MORE

7. 5. Environment-Sensitive Multifunctional Drug Delivery Systems

   Author : Jian Qin; Mamoun Muhammed; Marcus Textor; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Materials chemistry; Materialkemi;

   Abstract : Drug delivery systems (DDS) with multiple functionalities such as environment-sensitive drug release mechanisms and visualization agents have motivated the biomedical community as well as materials chemists for more than a decade. This dissertation is concerned with the development of nanoparticles for multifunctional DDS  to tackle several crucial challenges in these complex systems, including polymeric nanospheres which respond to temperature change, superparamagnetic iron oxide nanoparticles/polymeric composite for magnetic resonance imaging contrast agents and drug carriers, immunoresponse of nanomaterials and injectable magnetic field sensitive ferrogels. READ MORE