Search for dissertations about: "local immune responses"

Showing result 1 - 5 of 138 swedish dissertations containing the words local immune responses.

  2. 1. Mechanisms for immune escape in epithelial ovarian cancer

    Author : Pernilla Israelsson; Ulrika Ottander; Lucia Mincheva-Nilsson; Eva Lundin; Ivan Nagaev; Karin Sundfeldt; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; ovarian cancer; high-grade serous cancer; EOC; HGSC; HGSOC; tumor microenvironment; immune escape; immune suppression; cytokines; exosomes; NKG2D; MICA B; ULBP1-3; DNAM-1; surgery; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Tumors develop mechanisms to subvert the immune system, constituting immune escape. Epithelial ovarian cancer (EOC), the deadliest of all gynecological malignancies, uses a variety of mechanisms to undermine immune surveillance, aiding its establishment and metastatic spreading. READ MORE

  4. 2. Host modulation of excessive innate immune responses

    Author : Johannes Westman; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : A fundamental role of the innate immune system is to elicit a proper response against both invading pathogens and tissue damage or danger signals. Although the innate immune system often is successful in eliminating danger, an excessive host-response can result in severe tissue injury. READ MORE

  5. 3. Pathogen-mediated selection in the immune system of rodents : Exploring selection targets, functional effects and trade-offs

    Author : Mridula Nandakumar; Funktionell zoologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pathogen-mediated selection; bank voles; Myodes glareolus; immune system; balancing selection; immune response; rodents; positive selection; transcriptomics;

    Abstract : Pathogens cause disease and play an important role in shaping evolution of the host immune system. They create pressure on host immunity to evolve in numerous ways, most commonly by increasing divergence between species (positive selection) or increasing polymorphisms within a population (balancing selection). READ MORE

  6. 4. Immune responses to the Ro and La autoantigens

    Author : Pia Tengnér; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Sjögren s syndrome; systemic lupus erythematosus; Ro SS-A; La SS-B;

    Abstract : Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are rheumatic diseases characterized by autoantibody production directed to the Ro/SS-A and La/SS-B autoantigens. The Ro/SS-A is a complex of one of four small RNAs denoted hY RNAs, and three proteins; Ro 60kD, Ro 52kD and La. READ MORE

  7. 5. Drosophila immune responses in a model for epithelial hypertrophy

    Author : Robert Krautz; Ulrich Theopold; Hugo Stocker; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molecular Biology; molekylärbiologi;

    Abstract : Apoptosis, differentiation and proliferation have to be tightly balanced and thus regulated to maintain tissue homeostasis. Stress, metabolic cues, genetic variability, infections and physiological host-commensal interactions influence this balance and thus need to be integrated. Therefore, beyond the discrimination between self and non-self (i.e. READ MORE