Search for dissertations about: "lymphangiogenesis"

Showing result 1 - 5 of 20 swedish dissertations containing the word lymphangiogenesis.

2. 1. Lymphangiogenesis and lymphatic metastasis

   Author : Meit A Björndahl; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Angiogenesis; lymphangiogenesis; lymphatic metastasis; PDGF; IGF; VEGF-A;

   Abstract : The major cause of cancer mortality is metastasis, which relies on the growth of blood vessels (haemangiogenesis) and lymphatic vessels (lymphangiogenesis). Whereas the field of haemangiogenesis has been relatively thoroughly studied, little is known about the mechanisms regulating lymphangiogenesis. READ MORE

4. 2. From endothelial cells to the vascular network : How cell migration and proliferation are orchestrated to build lymphatic vessels

   Author : Di Peng; Katarzyna Koltowska; Vermot Julien; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lymphangiogenesis; Cell migration; Zebrafish; Biologi med inriktning mot zoologisk utvecklingsbiologi; Biology with specialization in Animal Development;

   Abstract : Lymphatic endothelial cells (LECs) migrate across body to form a branched network, which is crucial for fluid drainage and immune cell trafficking of the tissues. However, the molecular mechanisms behind the spatiotemporal regulation and fine-tuning of LEC migration remain largely unknown. READ MORE

5. 3. Molecular and Biological Characteristics of Stroma and Tumor Cells in Colorectal Cancer

   Author : Jingfang Gao; Xiao-Feng Sun; Richard Palmqvist; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carcinogenesis; genetic alterations; colorectal cancer CRC ; cysteine-histidine rich protein PINCH ; Inflammatory infiltration; Angiogenesis; lymphangiogenesis; Oncology; Onkologi;

   Abstract : Carcinogenesis is a progressive process involving multiple genetic alterations in tumor cells and complex interactions in the tumor-host microenvironment. To better understand the contribution of molecular alterations in tumor cells and stromal variables to the development of colorectal cancer (CRC) and identify prognostic factors, in this study we examined the clinicopathological and biological significance of stromal variables, including particularly interesting new cysteine-histidine rich protein (PINCH), inflammatory infiltration, angiogenesis and lymphangiogenesis, as well as hRAD50/hMRE11/hNBS1 proteins and hRAD50 mutation in tumor cell in CRC. READ MORE

6. 4. Invasive and Metastatic Properties of Advanced Prostate Cancer

   Author : Karin Jennbacken; Göteborgs universitet; []
   Keywords : Prostate cancer; Androgen-independent; Castration-resistant; Metastasis; Invasion; Lymphangiogenesis; Cell adhesion; N-cadherin; VEGF-C; MRI;

   Abstract : Prostate cancer is initially androgen-dependent (AD) and therefore androgen deprivation therapy (ADT) is generally used to treat advanced prostate cancer. However, the long-term treatment effects are insufficient and over time an androgen-independent (AI) tumor relapses, which is generally highly aggressive and metastatic. READ MORE

7. 5. Hypoxia, PDGF and VEGF in Vascular Development

   Author : Ingrid Nilsson; Lena Claesson-Welsh; Randall Johnson; Uppsala universitet; []
   Keywords : Cell biology; hypoxia; VEGF; VEGFR-3; PDGF; endothelial cell; embryonic stem cell; angiogenesis; lymphangiogenesis; Cellbiologi;

   Abstract : The mechanisms behind many important aspects of blood- and lymphatic vessel formation have yet not been elucidated in detail. The primary objectives of this thesis have therefore been to study the effects of hypoxia, platelet-derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs) on vascular development and function. READ MORE