Search for dissertations about: "lysosomal enzymes"

Showing result 1 - 5 of 29 swedish dissertations containing the words lysosomal enzymes.

  2. 1. Engineering enzymes towards biotherapeutic applications using ancestral sequence reconstruction

    Author : Natalie Hendrikse; Per-Olof Syrén; Johan Rockberg; Erik Nordling; Reinhard Sterner; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzyme engineering; enzyme evolution; ancestral sequence reconstruction; therapeutic enzymes; terpene cyclases; ammonia-lyases; sulfatases; lysosomal enzymes; Kemi; Chemistry;

    Abstract : Enzymes are versatile biocatalysts that fulfill essential functions in all forms of life and, therefore, play an important role in health and disease. One specific application of enzymes in life science is their use as biopharmaceuticals, which typically benefits from high catalytic activity and stability. READ MORE

  4. 2. Degranulation in macrophages and other leukocytes: regulation by calcium, phosphoinositide 3-kinase, and protein kinase C

    Author : Claes Nauclér; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lysosomal secretion; neutrophil; Clinical biology; proton pump; Klinisk biologi; exocytosis; lysosomal pH;

    Abstract : Macrophages mediate innate immunity through release of cytokines, eicosanoids, reactive oxygen species as well as through phagocytosis and secretion of lysosomal enzymes. Regulation of lysosomal secretion in macrophages differs in several respects from release of specialized granules in other leukocytes. READ MORE

  5. 3. Bleeding Oesophageal Varices. A Clinical Study of Mesocaval Interposition Shunting and Endoscopic Sclerotherapy

    Author : Björn Isaksson; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; repeated sclerotherapy; mesocaval interposition shunt; lysosomal enzymes; hepatic encephalopathy; bleeding oesophageal varices; Liver cirrhosis; portal hypertension; oesophageal manometry; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Abstract : This thesis is aimed at evaluating the clinical results of two treatments in patients with bleeding oesophageal varices; the mesocaval interposition shunt (MI shunt) and repeated endoscopic sclerotherapy (ST). 24 patients were randomised to MI shunt and 21 patients to the ST group (mean age 51.6?9.2 and 53. READ MORE

  6. 4. Oxidized Lipids and Lysosomal Pathology in Atherogenesis

    Author : Wei Li; Wendy Jessup; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Macrophages take up large amount of exogenous materials such as oxidatively modified low-density lipoproteins (oxLDL) and lysosomotropic agents. OxLDL is taken up into macrophage lysosomes through receptor-mediated endocytosis, but poorly degraded, resulting in foam cell formation. READ MORE

  7. 5. The Lysosomal-Mitochondrial Axis Theory of Apoptosis

    Author : Ming Zhao; Sten Orrenius; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : In many cases, apoptosis may be initiated by a minor lysosomal destabilization, which some time later is followed by a secondary, more pronounced, lysosomal rupture. After exposure to low concentrations of sphingosine, a lysosomotropic detergent, Jurkat and J774 cells underwenr apoptotic cell death, while cells exposed to higher concentrations of this agent showed necrosis. READ MORE