Search for dissertations about: "macrophages"

Showing result 1 - 5 of 743 swedish dissertations containing the word macrophages.

  2. 1. Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis

    Author : Frida Gorreja; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrophages; inflammatory macrophages; tissue-resident macrophages; efferocytosis; innate immunity; myeloid cells; fibroblasts; fibrosis; inflammasomes; Crohn´s disease; inflammatory bowel diseases; digestive diseases; mucosa immunology; intestinal immunity; intestinal inflammation; serum systemic inflammation; microbiota; metabolites;

    Abstract : Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune involvement. Therefore, in-terpreting macrophage activity in the intestinal microenvironment may identify treatment targets beneficial for at least a subgroup of patients. READ MORE

  4. 2. Cancer and Inflammation : Role of Macrophages and Monocytes

    Author : Alexander Hedbrant; Jonny Wijkander; Dick Delbro; Ann Erlandsson; Anita Sjölander; Karlstads universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; M1 macrophages; M2 macrophages; colon cancer; lung cancer; prostaglandin E2; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Macrophages are cells of the innate immune system that can be found in large quantities in cancer tumors and affect cancer progression by regulating growth and invasiveness of cancer cells. There are two main phenotypes of macrophages denoted M1 and M2. READ MORE

  5. 3. Monocytes and macrophages, with a focus of Crohn's disease

    Author : Susanne Thiesen; Internmedicin - epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Crohn s disease; Cystatin C; Cytokines; Intestine; Macrophages; Monocytes; Gene-expression;

    Abstract : Monocytes and macrophages are part of the body’s first line of defense, eliminating pathogens by phagocytosis or by releasing a broad array of inflammatory mediators, such as cytokines, chemokines and proteases. In humans, three subsets of monocytes are described with seemingly different functions. READ MORE

  6. 4. Signal transduction in macrophages. Intracellular pathways activated by microbial constituents

    Author : Sandra Olsson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; TNF; TLR; dectin-1; lipid rafts; Src; Btk; Macrophages; arachidonate;

    Abstract : Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. READ MORE

  7. 5. Macrophages and neutrophils in tissue homeostasis and recovery from ischemic injury

    Author : Kristel Parv; Mia Phillipson; Gustaf Christoffersson; Per-Ola Carlsson; Stephen Jenkins; Uppsala universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrophages; neutrophils; hindlimb ischemia; ischemic disease; mural cells; diabetes mellitus; postnatal β cell maturation.;

    Abstract : Neutrophils and macrophages have functions beyond protection against pathogens. The overall aim of the work presented in this thesis was to identify novel tasks for these innate immune cells in maintaining homeostasis. READ MORE