Search for dissertations about: "malignancies"

Showing result 1 - 5 of 360 swedish dissertations containing the word malignancies.

  1. 1. Malignancies in Sweden after the Chernobyl accident in 1986

    University dissertation from Institutionen för molekylär och klinisk medicin

    Author : Martin Tondel; Linköpings universitet.; Linköpings universitet.; Östergötlands Läns Landsting.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epidemiology; Environmental; Chernobyl; ionising radiation; geographical information systems GIS; 8-OHdG; Malignancies; Low dose; Dose-response; Latency; Causalty; MEDICINE Social medicine Public health medicine research areas Epidemiology; MEDICIN Socialmedicin Folkhälsomedicinska forskningsområden Epidemiologi;

    Abstract : On 26 April 1986 an accident occurred in the Chernobyl nuclear power plant resulting in the release of large amount of radionuclides. Almost five percent of the total released caesium-137 was deposited in Sweden. The incidence of malignancies in the most affected counties in Sweden was investigated in three epidemiological studies. READ MORE

  2. 2. Recurrent Genetic Mutations in Lymphoid Malignancies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Emma Young; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphoid malignancies; mutations; CLL; stereotypy; subsets; PMBL; NFKBIE; EGR2; whole-genome sequencing; Molekylär genetik; Molecular Genetics; Oncology; Onkologi;

    Abstract : In recent years, the genetic landscape of B-cell derived lymphoid malignancies, including chronic lymphocytic leukemia (CLL), has been rapidly unraveled, identifying recurrent genetic mutations with potential clinical impact. Interestingly, ~30% of all CLL patients can be assigned to more homogeneous subsets based on the expression of a similar or “stereotyped” B-cell receptor (BcR). READ MORE

  3. 3. Angiogenesis in childhood malignancies

    University dissertation from Uppsala : Institutionen för kirurgiska vetenskaper

    Author : Erik Sköldenberg; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Angiogenesis Factor; Biopsy; Needle; Neovascularization; Pathologic; Nephroblastoma; Reference value; Kirurgi; MEDICINE Surgery; MEDICIN Kirurgi; kirurgi; särskilt barnkirurgi; Pediatric Surgery;

    Abstract : Angiogenesis is necessary for the growth and spread of solid tumors. In these studies angiogenesis was measured in childhood malignancies in general and in Wilms’ tumor in particular, and cutting needle biopsy (CNB) specimens were evaluated for diagnosis in childhood renal tumors. READ MORE

  4. 4. Trisomies in Hematologic Malignancies

    University dissertation from Section of Clinical Genetics, Institution of Laboratory Medicine, Lund University Hospital

    Author : Kajsa Paulsson; Lunds universitet.; Lund University.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; Klinisk genetik; cytogenetik; Genetik; cytogenetics; Genetics; leukemia; chromosome aberration; trisomy;

    Abstract : Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.. READ MORE

  5. 5. Prognostic markers and DNA methylation profiling in lymphoid malignancies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sujata Bhoi; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphoid malignancies; CLL; MCL; prognostic markers; micro-RNA; methylation; stereotyped subsets;

    Abstract : In recent years, great progress has been achieved towards identifying novel biomarkers in lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), at the genomic, transcriptomic and epigenomic level for accurate risk-stratification and prediction of treatment response. In paper I, we validated the prognostic relevance of a recently proposed RNA-based marker in CLL, UGT2B17, and analyzed its expression levels in 253 early-stage patients. READ MORE