Search for dissertations about: "malignancies"

Showing result 16 - 20 of 492 swedish dissertations containing the word malignancies.

  2. 16. CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside

    Author : Hannah Karlsson; Angelica Loskog; Karl-Johan Malmberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; chimeric antigen receptors; CAR T cells; T cell therapy; immunotherapy; CD19; Bcl-2 family inhibitors; B cell malignancies; Klinisk immunologi; Clinical Immunology;

    Abstract : Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. READ MORE

  4. 17. Multiple primary malignancies in breast cancer patients. From population study to genetics

    Author : Jenny Nyqvist; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; multiple primary malignancies; genetic alterations;

    Abstract : Breast cancer (BC) is one of the most common causes of cancer-related death among women worldwide. Due to early detection of BC and more tailor-made treatments, patients live longer despite their illness. Studies have shown that BC patients are at risk of developing new tumors in organs other than the breast, mainly caused by BC treatment. READ MORE

  5. 18. Inverted papilloma and sinonasal malignancies in Sweden

    Author : Alexandra Elliot; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Sinonasal malignancies (SNMs) are rare and in Sweden they account for approximately 0,1% of all malignancies and 5% of all head and neck malignancies. Apart from sinonasal malignant melanoma (SNMM), their incidence has been reported to decrease since 1960 while the survival rates have remained rather stable during the same time-period. READ MORE

  6. 19. Bloodstream infections in patients with hematological malignancies

    Author : Christian Kjellander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Patients with hematological malignancies have an increased risk of infectious complications. These complications can be caused by disease-specific factors or be treatment-related. Bloodstream infections increase the risk of morbidity, mortality, have a negative impact on quality of life, and may lead to reductions in treatment intensity. READ MORE

  7. 20. Real-world studies on B-cell malignancies

    Author : Anna Asklid; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Randomized controlled trials remain the preferred way of evaluating new treatments. However, in studies on malignancies, trial data may not always be sufficient to address the requirements of health care providers and regulatory agencies regarding recommendations as patients are strictly selected through inclusion- and exclusion criteria. READ MORE