Search for dissertations about: "markers in diabetic nephropathy"

Showing result 1 - 5 of 11 swedish dissertations containing the words markers in diabetic nephropathy.

  2. 1. Metabolic aspects on diabetic nephropathy

    Author : Maria Svensson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; invärtesmedicin; Internal Medicine;

    Abstract : Diabetic nephropathy (DN) is associated with morbidity and mortality due to cardiovascular disease and renal failure. This study focused on the impact of glycemic control on the development of DN and the metabolic consequences of DN. The euglycemic hyperinsulinemic clamp technique was used to assess insulin sensitivity and insulin clearance. READ MORE

  4. 2. Aspects of the glomerular barrier in healthy and diabetic kidneys

    Author : Marie Jeansson; Göteborgs universitet; []
    Keywords : glomerular size and charge selectivity; isolated perfused kidney; electron microscopy; glycocalyx; diabetic nephropathy; NOD mice;

    Abstract : Each day 180 liters of plasma is filtered in the kidneys. Under normal conditions, the glomerular barrier restricts the passage of macromolecules such as albumin while it is highly permeable to water and small solutes. Proteinuria is a hallmark of renal disease and reflects impairment of the glomerular barrier. READ MORE

  5. 3. The role of hypoxia for the development of diabetic nephropathy : Temporal relationship and involvement of endothelin receptor signaling

    Author : Stephanie Franzén; Fredrik Palm; Pamela K. Carmines; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nephropathy; diabetes; hypoxia; EPR;

    Abstract : Diabetic nephropathy is one of the most common causes of end stage renal disease and develops in approximately one third of all diabetes patients. Disease progression is characterized by deteriorating glomerular filtration rate and escalating urinary albumin/protein excretion; both are used as clinical markers for disease progression. READ MORE

  6. 4. Macro- and microvascular complications of diabetes: Studies on NFAT (Nuclear Factor of Activated T-cells) as a novel target for the treatment of atherosclerosis and vascular dysfunction in diabetes

    Author : Fabiana Blanco; Diabetiska komplikationer; []
    Keywords : NFAT; VSMCs; Diabetes; Hyperglycemia; Aterosclerosis; Diabetic retinopathy; Oxidative stress;

    Abstract : Diabetes is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular complications) as well as microvascular disorders leading to damage of the small vessels and the development of retinopathy, nephropathy and neuropathy. The underlying pathogenesis is not clear, but hyperglycemia has been identified as an important risk factor. READ MORE

  7. 5. Genetics of complications in patients with type 2 diabetes

    Author : Sami Alkayyali; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genetics; genome-wide association studies; type 2 diabetes; diabetes complications.;

    Abstract : Type 2 diabetes (T2D) is a polygenic disease caused by an interaction between genetic and environmental factors such as low physical activity, smoking, and obesity. The disease is associated with devastating chronic microvascular (nephropathy, retinopathy, and neuropathy) and macrovascular (coronary heart disease and stroke) complications. READ MORE