Search for dissertations about: "medium spiny neurons"
Showing result 1 - 5 of 21 swedish dissertations containing the words medium spiny neurons.
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1. Characterisation of inputs and outputs of striatal medium spiny neurons in health and disease
Abstract : Striatal medium spiny neurons (MSNs) play a crucial role in various motor and cognitive functions. They are separated into those belonging to the direct pathway (dMSNs) and the indirect pathway (iMSNs) of the basal ganglia, depending on whether they express D1 or D2 type dopamine receptors, respectively. READ MORE
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2. Exploring the miRNA profile of medium spiny neurons using retrograde transport in rats
Abstract : The basal ganglia play an essential role in movement selection and control. It is therefore not surprising that they are central to neurodegenerative diseases like Parkinson’s disease and Huntington’s disease. READ MORE
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3. Modeling receptor induced signaling in MSNs : Interaction between molecules involved in striatal synaptic plasticity
Abstract : Basal Ganglia are evolutionarily conserved brain nuclei involved in several physiologically important animal behaviors like motor control and reward learning. Striatum, which is the input nuclei of basal ganglia, integrates inputs from several neurons, like cortical and thalamic glutamatergic input and local GABAergic inputs. READ MORE
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4. Untangling Cortico-Striatal Circuitry and its Role in Health and Disease - A computational investigation
Abstract : The basal ganglia (BG) play a critical role in a variety of regular motor and cognitive functions. Many brain diseases, such as Parkinson’s diseases, Huntington’s disease and dyskinesia, are directly related to malfunctions of the BG nuclei. READ MORE
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5. Computer Modelling of Neuronal Interactions in the Striatum
Abstract : Large parts of the cortex and the thalamus project into the striatum,which serves as the input stage of the basal ganglia. Information isintegrated in the striatal neural network and then passed on, via themedium spiny (MS) projection neurons, to the output stages of thebasal ganglia. READ MORE