Search for dissertations about: "melflufen"

Found 3 swedish dissertations containing the word melflufen.

  2. 1. Anticancer Activity of Melflufen : Preclinical Studies of a Novel Peptidase-Potentiated Alkylator

    Author : Sara Strese; Joachim Gullbo; Rolf Larsson; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancertherapy; preclinical studies; melflufen; aminopeptidase-potentiated; cancer; angiogenesis; Klinisk farmakologi; Clinical Pharmacology;

    Abstract : Melflufen (melphalan flufenamide, chemical name L-melphalanyl-p-L-fluorophenylalanine ethyl ester hydrochloride, previously called J1) is a derivative of the classical alkylating agent melphalan. Melflufen is potentiated by hydrolytic cleavage by aminopeptidase N (APN), leading to high intracellular concentrations of alkylating moieties and subsequent cell death. READ MORE

  4. 2. Potential New Drugs in Lymphoma

    Author : Maryam Delforoush; Gunilla Enblad; Mattias Berglund; Christina Drott; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphoma; diffuse large B-cell lymphoma; DLBCL; picropodophyllin; PPP; J1; melflufen; prodrug; cancer therapeutics; alkylating agents; b-AP15; proteasome inhibitors; DUB inhibition; UCHL5; USP14;

    Abstract : Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). READ MORE

  5. 3. Challenges in the management of urothelial cancer : novel treatment, evaluation of biomarkers, and imaging techniques

    Author : Carl-Henrik Shah; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Urothelial cancer (UC) is the most common malignancy found in the urinary tract. The global annual incidence is approximately 430 000 new cases (Sweden: 3 200 new cases). Approximately one in four new UC patients being diagnosed has muscle-invasive disease. READ MORE