Search for dissertations about: "membrane disruption"

Showing result 1 - 5 of 72 swedish dissertations containing the words membrane disruption.

2. 1. Antimicrobial Peptide Interactions with Phospholipid Membranes : Effects of Peptide and Lipid Composition on Membrane Adsorption and Disruption

   Author : Adam A Strömstedt; Martin Malmsten; Georges Belfort; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial; peptide; adsorption; liposome; membrane; melittin; cholesterol; tryptophan; phospholipid; bilayer; PHARMACY; FARMACI; Pharmaceutical Physical Chemistry; farmaceutisk fysikalisk kemi;

   Abstract : The interactions between antimicrobial peptides and phospholipid membranes were investigated, in terms of lipid headgroup variations and the role of cholesterol, as well as peptide composition and structure. Also strategies for increasing proteolytic stability were evaluated. READ MORE

4. 2. Distribution and Chemical Diversity of Cyclotides from Violaceae : Impact of Structure on Cytotoxic Activity and Membrane Interactions

   Author : Robert Burman; Ulf Göransson; Lars Bohlin; William Gerwick; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclotide; Violaceae; Viola; Cytotoxic; Mechanism; In vivo; Structure-activity; Membrane; Mass spectrometry; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi;

   Abstract : During the last decade there has been increased interest in the cyclotide protein family, which consist of a circular chain of approximately 30 amino acids, including six cysteines that form three disulfide bonds, arranged in a cyclic cystine knot motif. This thesis gives new insights in cyclotide distribution and occurrence in the plant family Violaceae, structure-activity relationships for cytotoxic effects, membrane disruption and adsorption on lipid membranes, and evaluates toxicity and anti-tumor activity in vivo. READ MORE

5. 3. Plasma membrane/cytoskeleton interactions in plants

   Author : Anders Sonesson; Lunds universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Triton X-114; hydrophobic tubulin; tubulin; actin; cytoskeleton; Brij 58; inside-out; plasma membrane; plant; cauliflower; Physiological biophysics; Växtfysiologi;

   Abstract : The way in which the cortical cytoskeleton associates to the plasma membrane (PM) must be elucidated to understand the structural dynamics of many processes in the plant cell. In the present study, isolated cauliflower (Brassica oleracea L.) PM vesicles were used to characterize membrane/cytoskeleton interactions. READ MORE

6. 4. Basement membrane components and their receptors in organogenesis

   Author : Katriina Salmivirta; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Basement membrane; laminin; collagen type IV; nidogen; integrin; morphogenesis; organogenesis; tooth; salivary gland; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; fysiologi; Physiology;

   Abstract : During embryogenesis organs are formed from epithelial and mesenchymal tissues. Organogenesis is dependent on interactions between epithelium and mesenchyme. Specialized extracellular matrices, basement membranes, located between the two tissue types play a crucial role in mediating the interactions. READ MORE

7. 5. Cytotoxic Cyclotides : Structure, Activity, and Mode of Action

   Author : Erika Svangård; Per Claeson; Lars Bohlin; Ulf Göransson; John H. Cardellina II; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; cyclotide; cytotoxic; cancer; cyclic cystine knot; Viola; Violaceae; liposome; hollow fibre; homology modelling; mass spectrometry; amphipathic; structure–activity; tumour; membrane disruption; necrosis; Farmakognosi; Pharmacognosy; Farmakognosi;

   Abstract : Cyclotides are small cyclic plant proteins, and this thesis addresses their cytotoxic structure-activity properties and their mode of action on human cancer cell lines. Cyclotides were isolated from Viola odorata and Viola tricolor; three novel cyclotide sequences and two known sequences, but of new origin, were identified using mass spectrometry, amino acid analysis, and Edman degradation. READ MORE