Search for dissertations about: "membrane permeability"

Showing result 1 - 5 of 143 swedish dissertations containing the words membrane permeability.

  2. 1. Intestinal absorption of drugs : The impact of regional permeability, nanoparticles, and absorption-modifying excipients

    Author : Carl Roos; Hans Lennernäs; Erik Sjögren; Martin Brandl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Permeability; intestinal absorption; regional permeability; nanoparticles; nanosuspensions; absorption-modifying excipients; AMEs; Biofarmaci; Biopharmaceutics;

    Abstract : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. READ MORE

  4. 2. Free Volume and Mesopores in Polymer Nanocomposites

    Author : Petra Winberg; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemical technology and engineering; Kompositmaterial; Composite materials; Macromolecular chemistry; permeability ; membrane ; positron annihilation ; fumed silica ; clay ; mesopores ; polymer nanocomposites ; free volume ; Kemiteknik och kemisk teknologi; Makromolekylär kemi;

    Abstract : The free volume in polymers is coupled to several important physical properties, such as density, viscosity and gas diffusivity. The physical properties of polymers close to a solid surface have been shown to be significantly perturbed as compared to their bulk state. READ MORE

  5. 3. Cell Membrane Homeostasis in Mammals - The roles of ADIPOR2 and TLCD1 & 2

    Author : Henrik Palmgren; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Membrane lipids; Membrane fluidity; Membrane homeostasis; Dietary lipids; Phospholipids; Genetics; Lipotoxicity; Lipidomics; ADIPOR2; TLCD1; TLCD2;

    Abstract : Ten nanometers. That is the approximate thickness of the plasma membrane that separates the extracellular space from the entire cellular machinery. An asymmetrical bilayer consisting of predominantly phospholipids in which proteins and carbohydrates are anchored and exert their function. READ MORE

  6. 4. ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition

    Author : Pär Matsson; Per Artursson; Ulf Norinder; Peter Swaan; Uppsala universitet; []
    Keywords : Pharmaceutics; ATP-binding cassette; ABC transporter; P-gp; P-glycoprotein; ABCB1; BCRP; Breast cancer resistance protein; ABCG2; MRP2; Multidrug-resistance associated protein 2; ABCC2; Membrane permeability; Drug transport; Active transport; Passive diffusion; Multivariate data analysis; PLS; OPLS; QSAR; Galenisk farmaci;

    Abstract : Transport into and across the cells of the human body is a prerequisite for the pharmacological action of drugs. Passive membrane permeability and active transport mechanisms are major determinants of the intestinal absorption of drugs, as well as of the distribution to target tissues and the subsequent metabolism and excretion from the body. READ MORE

  7. 5. Membrane Fluidity Regulation: From C. elegans to mammalian cells

    Author : Ranjan Devkota; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PAQR-2; adiponectin receptors; IGLR-2; saturated fats; membrane fluidity; fatty acid desaturation; unsaturated fatty acid; membrane homeostasis;

    Abstract : Biological membranes are primarily an assembly of lipids and proteins. Collectively, these constituents within a phospholipid bilayer determine the physical membrane properties such as fluidity, viscosity, thickness, packing and permeability. Maintenance of membrane properties within acceptable margins, i.e. READ MORE