Search for dissertations about: "methacholine"
Showing result 1 - 5 of 31 swedish dissertations containing the word methacholine.
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1. Optimizing and evaluation of a methacholine provocation test : with application in occupational research
Abstract : We have developed a methacholine provocation method, which detects bronchial responsiveness in more than 80% of healthy subjects. The method enables us to detect differences in bronchial responsiveness within the normal range. With this method FEV1 and Gaw had similar sensitivity in detecting small differences in bronchial responsiveness. READ MORE
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2. Clinical studies of asthma phenotypes focusing on the role of the leukotrienes
Abstract : Inflammation in the airways in connection to asthma is a complex phenomenon and the mechanisms underlying the associated clinical symptoms involve the interaction of many different kinds of cells and mediators, giving rise to different phenotypes. The aim of the present thesis was to investigate the molecular and cellular mechanisms that results in two of these phenotypes, i. READ MORE
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3. Allergy to laboratory animals : risk factors for development of allergy and methods for measuring airborne rodent allergens
Abstract : Between 10-50% of workers exposed to laboratory animals, mainly rats or mice, develop laboratory animal allergy (LAA) with symptoms of rhinitis, conjuctivitis, asthma, or urticaria, and IgE against animal allergens. Symptoms often arise within the first years of animal work. Up to half of the symptomatic subjects develop asthma. READ MORE
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4. Airway responsiveness and exhaled nitric oxide : Studies in asthma and Sjögren's syndrome
Abstract : In this thesis, four different types of provocation agents: methacholine, adenosine, cold air and mannitol were used to study different aspects of the airway responsiveness profile in asthma and Sjögren's syndrome. Exhaled nitric oxide (NO) and markers of eosinophil activation, serum eosinophil peroxidase (S-EPO) and eosinophil cationic protein (S-ECP) were measured. READ MORE
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5. Effects of glucocorticoids or beta 2-agonists on inflammatory responses induced by organic dust in vitro and in vivo
Abstract : Exposure of healthy subjects in a swine barn causes an acute inflammatory response in the airways and an increase in bronchial responsiveness to methacholine. The aim of this thesis was to study the mechanisms by which glucocorticoids or Beta2-agonists interfere with the inflammatory response following swine house dust-exposure both in vitro and in vivo. READ MORE