Search for dissertations about: "methylated metabolites"
Found 5 swedish dissertations containing the words methylated metabolites.
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1. Clinical studies of thiopurine metabolism in inflammatory bowel disease
Abstract : Inflammatory bowel disease (IBD, i.e. primarily Crohn's disease and ulcerative colitis) is characterised by a chronic or relapsing inflammation of the digestive tract. READ MORE
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2. Exposure to inorganic arsenic in pregnancy and metabolism-nutrition interaction
Abstract : Inorganic arsenic is metabolized by most mammals, including humans, via alternating reduction and oxidative methylation with S-adenosylmethionine as main methyl donor. Thus, it seems likely that it is influenced by the availability of methyl groups. READ MORE
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3. Bioanalytical development for application in therapeutic drug monitoring : focus on drugs used in psychiatry
Abstract : Introduction: Since the 1950s and onwards, many new psychoactive drugs have been successfully introduced in clinical practice. A common feature of these drugs is a profound metabolism before clearance from the body. READ MORE
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4. Interindividual differences in thiopurine metabolism : studies with focus on inflammatory bowel disease
Abstract : The thiopurines, 6-mercaptopurine and its prodrug azathioprine, are used in the treatment of inflammatory bowel disease, ulcerative colitis and Crohn´s disease. The main active metabolites are the phosphorylated thioguanine nucleotides (6-TGNs) and methylated thioinosine monophosphate (meTIMP). READ MORE
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5. Developmental immunotoxicity of early-life arsenic exposure
Abstract : Arsenic exposure, mainly via drinking water and certain food, is a major public health concern because of its association with various types of cancers and other non-cancer adverse health effects. Worldwide, more than one hundred million people are exposed to elevated levels of arsenic on a regular basis. READ MORE