Search for dissertations about: "micro-dissection"

Found 5 swedish dissertations containing the word micro-dissection.

2. 1. Early effects of castration therapy in non-malignant and malignant prostate tissue

   Author : Nina Ohlson; Pernilla Wikström; Anders Bergh; Pär Stattin; Marja Nevalainen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; human biopsies; androgen ablation; stroma; epithelium; micro-dissection; PSA; IGF-1; IGF-R1; AR; Pathology; Patologi;

   Abstract : Early Effects of Castration Therapy in Non-malignant and Malignant Prostate Tissue BACKGROUND. Androgen ablation, the standard treatment for advanced prostate cancer, results in increased apoptosis, decreased cell proliferation and subsequent involution of the prostate gland. READ MORE

4. 2. Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor

   Author : Sofia Halin; Anders Bergh; Pernilla Wikström; Stina Rudolfsson; Carl-Henrik Heldin; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; angiogenesis; castration therapy; microenvironment; stroma; tumor-associated macrophages; pigment epithelium-derived factor; PEDF; vasculature; Pathology; Patologi; patologi; Pathology;

   Abstract : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. READ MORE

5. 3. Molecular epidemiologic studies on helicobacter pylori infection and stomach cancer risk

   Author : Zongli Zheng; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Helicobacter pylori;

   Abstract : Helicobacter pylori (H. pylori) infection increases stomach cancer risk. The aim of this thesis was to study genetic susceptibility from the host and to develop molecular methods for future characterization of bacterial virulence factors in longitudinal cohorts. READ MORE

6. 4. Examining the prostate stroma and vasculature : importance and potential as targets for therapy

   Author : Anna Johansson; Anders Bergh; Arne Östman; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration therapy; vasculature; stroma; the angiopoietins; the PDGF-receptors; mast cells; Pathology; Patologi;

   Abstract : Background. Recent studies in cancer research have focused on the reciprocal interaction between cancer cells and their microenvironment. Tumour growth is angiogenesis dependent and the rate of angiogenesis correlates with a poor prognosis in many different cancers. READ MORE

7. 5. Development of intimal hyperplasia in transplant arteriosclerosis

   Author : Piotr Religa; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Vascular disease is the main cause of disability and mortality in the western world and the major limiting factor for long- term survival of transplanted organs. Occlusive vascular lesions lead to ischemia and structural changes in organs and in transplant arteriosclerosis and restenosis after endovascular procedures, narrowing of the vessel lumen is partly due to intimal hyperplasia caused by smooth muscle cells (SMCs). READ MORE