Search for dissertations about: "microgel"

Showing result 1 - 5 of 20 swedish dissertations containing the word microgel.

2. 1. Microgel Interactions with Peptides and Proteins : Consequence of Peptide and Microgel Properties

   Author : Ronja Widenbring; Martin Malmsten; Per Hansson; Catherine Picart; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Binding; Degradation; Enzyme; Gel; Hydrogel; Microgel; Peptide; Protein; Release; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

   Abstract : Microgels are lightly cross-linked hydrogel particles in the sub-micrometer to micrometer size range with a capacity to drastically change their volume in response to changes in the external environment. Microgels have an ability to bind and store substances such as biomacromolecular drugs, notably proteins and peptides, and release them upon stimuli, making them potential candidates as drug delivery vehicles and functional biomaterials. READ MORE

4. 2. Fluids, Gels and Crystals : Phase behavior of binary thermoresponsive microgel mixtures

   Author : Jasper Immink; NanoLund: Centre for Nanoscience; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; colloidal phase behavior; microgel; binary mixture; colloidal gel; sequential gelation; patchy particle; binary crystal; crystal-to-crystal transition;

   Abstract : Thermoresponsive colloidal microgels expel solvent from their interior upon crossing a threshold temperature, resulting in a significantly reduced size. The collapse of microgels can reversibly switch the interparticle interactions from soft repulsive to attractive, and the accompanying size reduction allows for precise control over volume fraction. READ MORE

5. 3. Interaction Between Microgels and Oppositely Charged Proteins

   Author : Christian Johansson; Per Hansson; Brian Saunders; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; microgel; protein; uptake; distribution; core-shell; colloidal stability; Physical chemistry; Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

   Abstract : This thesis reports on interactions between microgels and oppositely charged proteins. Two types of negatively charged microgels are investigated: poly(acrylic acid) microgels of 60-80 µm in diameter, and colloidal poly(NIPAM-co-acrylic acid) microgels of around 1 µm in diameter. READ MORE

6. 4. Microgels as drug delivery vehicles : loading and release of amphiphilic drugs

   Author : Yassir Al-Tikriti; Per Hansson; Magnus Bergström; Matthew Libera; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microgel; amphiphilic drug; phase separation; micropipette; Raman microscopy; controlled release; drug delivery; SAXS; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

   Abstract : Polyelectrolyte microgels are used as delivery vehicles for amphiphilic drugs in, e.g., treatments of liver cancer by a method called trans-arterial chemoembolization. READ MORE

7. 5. In vitro evaluation of formulations used in the treatment of hepatocellular carcinoma

   Author : Emelie Ahnfelt; Hans Lennernäs; Erik Sjögren; Niklas Axén; Jesper Østergaard; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug delivery system; Doxorubicin; Microgel; Emulsion; Hepatocellular carcinoma; Biofarmaci; Biopharmaceutics;

   Abstract : Hepatocellular carcinoma (HCC) causes ~ 600,000 deaths annually, making it the second most deadly cancer form. HCC is classified into five stages and for the intermediate HCC treatment, the two most commonly used drug delivery systems (DDSs) are lipiodol-based emulsions and drug-eluting beads. READ MORE