Search for dissertations about: "microparticles and vaccine"

Found 5 swedish dissertations containing the words microparticles and vaccine.

  2. 1. Effects of Microparticulate Drug Delivery Systems : Tissue Responses and Transcellular Transport

    Author : Eva Ragnarsson; Per Artursson; Lucia Lazorova; David Brayden; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; microparticles; vaccine; pDNA vaccine; cationic polymer; gene expression analysis DNA array ; Caco-2; follicle-associated epithelium FAE ; M cell; transcytosis; Yersinia pseudotuberculosis; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : Over the past decade, the development of macromolecular drugs based on peptides, proteins and nucleic acids has increased the interest in microparticulate drug delivery, i.e., the delivery of drug systems in the nanometer and micrometer ranges. READ MORE

  4. 2. Development of a New Oral Vaccine against Diphtheria and the Study of its Immunogenicity in Mouse and Man

    Author : Niclas Rydell; Ingvar Sjöholm; Sveinbjörn Gizurarson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; oral vaccination; mucosal vaccination; diphtheria; biodegradable; microparticles; starch; CRM197; adjuvant; vaccine; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : Most pathogens enter the body via mucosal surfaces. In contrast to parenterally administered vaccination, mucosal vaccination has the advantage of eliciting both a systemic and a local mucosal immune response. An oral biodegradable adjuvant with these features would have great potential. READ MORE

  5. 3. Starch Microparticles as an Oral Vaccine Adjuvant with Emphasis on the Differentiation of the Immune Response

    Author : Linda Stertman; Ingvar Sjöholm; Kjell-Olov Grönvik; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Vaccine adjuvant; Microparticles; Oral immunisation; Th1 Th2 differentiation; Mucosal immune response; Uptake; M cell; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : Polyacryl starch microparticles have been developed as an oral vaccine adjuvant capable of inducing strong local and systemic immune responses in mice. In this thesis, the starch microparticles were studied in order to increase basic understanding of their function. READ MORE

  6. 4. The Horizontal Ussing Chamber Method in Studies of Nasal Drug Delivery : Method Development and Applications Using Different Formulations

    Author : Karin Östh; Anna-Lena Ungell; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The results from this thesis leads to the following conclusions; HUM is a useful tool that fills a gap in the in vitro methods previously available to study nasal drug delivery. Using HUM, the pig respiratory nasal mucosa can obtain acceptable viability and retain it longer than the period of time needed for a transport experiment. READ MORE

  7. 5. Mucosal Vaccination Using Polyacryl Starch Microparticles as Adjuvant with Salmonella enteritidis as a Model Pathogen

    Author : Lena Strindelius; Ingvar Sjöholm; Mary Jo Wick; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; mucosal vaccination; polyacryl starch microparticles; salmonella enteritidis; flagellin; fimbriae; rCTB; LPS; Ussing chamber; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Abstract : Polyacryl starch microparticles have been developed as a new mucosal vaccine adjuvant intended for use in oral vaccination. The main objectives of this thesis were to evaluate the efficacy of these polyacryl starch microparticles and to study their uptake through mucosal tissues. READ MORE