Search for dissertations about: "microwave-assisted chemistry"

Showing result 1 - 5 of 32 swedish dissertations containing the words microwave-assisted chemistry.

  1. 1. On the Versatility of Microwave-Assisted Chemistry Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Kristina M. Orrling; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microwave-assisted chemistry; malaria; aspartic protease; plasmepsin; PfPM4; PmPM4; PoPM4; PvPM4; inhibitor; unsaturated lactone; unsaturated lactam; unsaturated amide; lactam; Bestmann s ylide; ionic liquid; polymerase chain reaction; thermophilic enzyme; NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry; NATURVETENSKAP Kemi Organisk kemi Läkemedelskemi; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Abstract : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. READ MORE

  2. 2. Recent Extraction Techniques with Emphasis on Supercritical Fluid Extraction and Microwave-assisted Extraction

    University dissertation from Cecilia Sparr Eskilsson, Analytical Chemistry, Lund University

    Author : Cecilia Sparr Eskilsson; Lunds universitet.; Lund University.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytisk kemi; Analytical chemistry; Pressurized hot water extraction; Pressurized liquid extraction; Microwave-assisted extraction; Recent extraction techniques; Supercritical fluid extraction;

    Abstract : Popular Abstract in Swedish För att kunna mäta ett ämnes halt i ett prov behövs en analysmetod. Det första steget i en analysmetod innefattar provupparbetning. Med det menas att ämnet man vill mäta halten av avskiljs (extraheras) från provet med någon sorts extraktionsteknik. READ MORE

  3. 3. Synthesis and biological evaluation of Bicyclic β-Lactams and 2-Pyridinones Pilicides Targeting Pilus Biogenesis in Pathogenic Bacteria

    University dissertation from Umeå : Department of Chemistry, Organic Chemistry, Umeå University

    Author : Hans Emtenäs; Umeå universitet.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; β-lactam; 2-pyridinone; 2-pyridone; Meldrum’s acid; Δ2-thiazoline; solid-phase synthesis; microwave assisted synthesis; antibacterial; pili; pilicide; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : New methods have been developed for the synthesis of bicyclic β-lactams and 2-pyridinones by combining acyl Meldrum’s acids and Δ2-thiazolines. The 2-pyridinones were synthesised both in solution using conventional heating or microwave assisted heating as well as by solid supported chemistry. READ MORE

  4. 4. Microwave-Assisted Synthesis of C2-Symmetric HIV-1 Protease Inhibitors Development and Applications of In Situ Carbonylations and other Palladium(0)-Catalyzed Reactions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Wannberg; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV; protease inhibitors; palladium; carbonylations; molybdenum hexacarbonyl; dihydropyrimidone; DHPM; microwave; cross-coupling; diazylhydrazines; carbon monoxide; synthesis; C2-symmetric; HIV-1 protease inhibitors; aminocarbonylation; fluorous; Farmaceutisk kemi; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi;

    Abstract : The HIV protease is an essential enzyme for HIV replication and constitutes an important target in the treatment of HIV/AIDS. Efficient combination therapies using inhibitors of the reverse transcriptase and protease enzymes have led many to reevaluate HIV infections from a terminal condition to a chronic-but-manageable disease in the developed world. READ MORE

  5. 5. Fast Chemistry by Microwave Heating : First Descriptions of Highly Enantioselective Microwave Protocols for Metal Catalysis; First Descriptions of in-situ Gas Generation for Fast Combinatorial Microwave Chemistry

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Nils-Fredrik K. Kaiser; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; organisk farmaceutisk kemi; Organic Pharmaceutical Chemistry;

    Abstract : Microwave heating was applied to different palladium-catalyzed allylic substitution reactions. The use of various nucleophiles demonstrated C-, N-, O- and S- nucleophilicity. High yields and stereopurities of the corresponding alkyls, amides, ethers and sulfones were afforded after only 30 – 120 s of heating. READ MORE