Search for dissertations about: "mismatch discrimination"

Showing result 1 - 5 of 10 swedish dissertations containing the words mismatch discrimination.

  2. 1. Biosensor technology applied to hybridization analysis and mutation detection

    Author : Peter Nilsson; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; biosensor; genosensor; surface plasmon resonance; hybridization; nucleic acids; oligonucleotide; mutation detection; mismatch discrimination; modular; Bioengineering; Bioteknik;

    Abstract : This thesis demonstrates the application of biosensor technology for molecular biology investigations, utilizing a surface plasmon resonance based optical device for mass sensitive detection of biomolecular interactions at a chipsurface. Oligonucleotide model systems were designed for analysis of the action of DNA manipulating enzymes. READ MORE

  4. 2. Cell-penetrating peptides, novel synthetic nucleic acids, and regulation of gene function : Reconnaissance for designing functional conjugates

    Author : Peter Guterstam; Ülo Langel; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptide; nucleic acids; alternative splicing; mismatch discrimination; Neurochemistry; Neurokemi;

    Abstract : Our genome operates by sending instructions, conveyed by mRNA, for the manufacture of proteins from chromosomal DNA in the nucleus of the cell to the protein synthesizing machinery in the cytoplasm. Alternative splicing is a natural process in which a single gene can encode multiple related proteins. READ MORE

  5. 3. Conformationally Constrained Nucleosides, Nucleotides and Oligonucleotides : Design, Synthesis and Properties

    Author : Dmytro Honcharenko; Jyoti Chattopadhyaya; Piet Herdewijn; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; antisense oligonucleotides; conformationally constrained nucleosides; azetidine; aza-ENA; target affinity; RNase H; exonuclease stability; pyrene-functionalized nucleotides; fluorescence; mismatch discrimination; Bioorganisk kemi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : This thesis is based on six original research publications describing synthesis, structure and physicochemical and biochemical analysis of chemically modified oligonucleotides (ONs) in terms of their potential diagnostic and therapeutic applications. Synthesis of two types of bicyclic conformationally constrained nucleosides, North-East locked 1',2'-azetidine and North locked 2',4'-aza-ENA, is described. READ MORE

  6. 4. Perceptual reorganization of vowels : Separating the linguistic and acoustic parts of the mismatch response

    Author : Ellen Marklund; Francisco Lacerda; Iris-Corinna Schwarz; Riitta Salmelin; Stockholms universitet; []
    Keywords : HUMANIORA; HUMANITIES; language acquisition; infants; speech perception; MMR; MMN; perceptual reorganization; Linguistics; lingvistik;

    Abstract : During the first year of life, infants go from perceiving speech sounds primarily based on their acoustic characteristics, to perceiving speech sounds as belonging to speech sound categories relevant in their native language(s). The transition is apparent in that very young infants typically discriminate both native and non-native speech sound contrasts, whereas older infants show better discrimination for native contrasts and worse or no discrimi­na­tion for non-native contrasts. READ MORE

  7. 5. Auditory event-related potentials and cognitive outcome after very preterm birth

    Author : Holger Hövel; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Preterm; Event-related potentials; Mismatch negativity; Magnetic resonance imaging; developmental outcome;

    Abstract : Children born before 32 gestational weeks have a high incidence of neuropsychological deficits. The structural and functional correlates of such impairments in preterm infants are incompletely understood, and early diagnostic tools are needed, but still lacking. READ MORE