Search for dissertations about: "molecular mechanisms"
Showing result 1 - 5 of 2278 swedish dissertations containing the words molecular mechanisms.
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1. Cytochrome c Oxidase dysfunction in cancer : Exploring the molecular mechanisms
Abstract : Mutations in genes encoding the mitochondrial enzyme Cytochrome c Oxidase (CytcO) have lately been found in connection to various types of cancer. Some mutations result in substitutions of highly conserved amino-acid residues. READ MORE
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2. Virulence mechanisms of pathogenic Yersinia : aspects of type III secretion and twin arginine translocation
Abstract : The pathogenic bacteria Yersinia pestis and Y. pseudotuberculosis are related to the degree where the former is considered a subspecies of the latter, and still they cause disease of little resemblance in humans. Y. pestis is the causative agent of lethal bubonic and pneumonic plague, while Y. READ MORE
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3. Ligand binding and enzyme catalysis studied by molecular dynamics simulations
Abstract : Molecular dynamics simulations and free energy calculations can be applied to biomolecular systems to predict ligand binding affinities. Combined with hybrid quantum-classical potential energy surfaces, such computations can also be used to probe enzymatic catalysis mechanisms. READ MORE
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4. Molecular Signatures of Cancer
Abstract : Cancer is an important public health concern in the western world, responsible for around 25% of all deaths. Although improvements have been made in the diagnosis of cancer, treatment of disseminated disease is inefficient, highlighting the need for new and improved methods of diagnosis and therapy. READ MORE
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5. Molecular Regulation of Angiogenesis
Abstract : Angiogenesis, de novo formation of blood vessels from the pre-existing vasculature, is crucial in embryo development, and in processes in the adult such as wound healing and ovulation. Angiogenesis is also involved in pathological conditions such as cancer and chronic inflammatory diseases, which are propagated by dysregulated, excess angiogenesis. READ MORE