Search for dissertations about: "monoclonal antibody therapy"
Showing result 1 - 5 of 72 swedish dissertations containing the words monoclonal antibody therapy.
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1. Targeted Therapy of Colorectal Cancer : Preclinical Evaluation of a Radiolabelled Antibody
Abstract : Targeted radiotherapy (TRT) of cancer is a promising approach that enables selective treatment of tumour cells, while sparing normal tissue. The humanized monoclonal antibody A33 (huA33) is a potential targeting agent for TRT of colorectal cancer, since its antigen is expressed in more than 95 % of all colorectal carcinomas. READ MORE
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2. Immunomodulatory Therapy of Solid Tumors : With a Focus on Monoclonal Antibodies
Abstract : Cancer, historically considered a genetic disease, is currently acknowledged to affect the whole body. Our immune system is one key player that can elicit a response against malignant cells but can also promote tumorigenesis. Tumors avoid immune recognition by creating a suppressive microenvironment and inducing tolerance. READ MORE
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3. Antibody-Based Radionuclide Targeting for Diagnostics and Therapy : Preclinical Studies on Head and Neck Cancer
Abstract : Antibody-based targeting techniques play an increasingly important role in cancer research. By targeting a structure that is abundant in tumour cells, but rare in healthy tissues, an antibody can mediate the delivery of radioactivity specifically to tumour cells in the body. READ MORE
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4. Targeted monoclonal antibody therapy in chronic lymphocytic leukemia
Abstract : Chronic lymphocytic leukemia (CLL) is still regarded as an incurable disease with a great need for developing new therapies and optimizing existing treatment options. The development of targeted therapy, i.e. therapy interfering with specific molecules needed for carcinogenesis and tumor growth, is rapidly evolving. READ MORE
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5. Epitope mapping of antibodies towards human protein targets
Abstract : This thesis, based on five research papers, presents results from development and evaluation ofmethods for identifying the interaction site of antibodies on their antigens and the functional investigation of these in different assays. As antibodies have proven to be invaluable tools in diagnostics, therapy and basic research, the demand of characterizing these binding molecules has increased. READ MORE