Search for dissertations about: "monozygotic"

Showing result 1 - 5 of 64 swedish dissertations containing the word monozygotic.

  2. 1. Post-zygotic Genetic Variation in Health and Disease

    Author : Hamid Reza Razzaghian; Jan P. Dumanski; David Gisselsson Nord; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Post-zygotic genetic variation; monozygotic twins; copy number variation; single nucleotide polymorphism; variable number tandem repeat; Medical Genetics; Medicinsk genetik;

    Abstract : Post-zygotic genetic variation has previously been shown in healthy individuals and linked to various disorders. The definition of post-zygotic or somatic variation is the existence of genetically distinct populations of cells in a subject derived from a single zygote. READ MORE

  4. 2. Complement-mediated kidney diseases: Genotype, phenotype and inhibition studies

    Author : S.S. Aradottir; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; The complement system; factor B; factor D; danicopan; Atypical hemolytic uremic syndrome; C3 glomerulopathy; Membranoproliferative glomerulonephritis; genes; monozygotic twins;

    Abstract : Complement-mediated kidney diseases are ultrarare conditions characterized by excess complement activation related in most cases to complement gene variants or circulating autoantibodies. These conditions are chronic and can lead to kidney failure. READ MORE

  5. 3. Defense-related inhibition of sympathetic nerve activity: Insights from neuroimaging and monozygotic twins on related cortical processes and clinical potential

    Author : John Jonsson Eskelin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microneurography; MEG; EEG; MRI; blood pressure; defence reaction; cortical autonomic network;

    Abstract : This thesis investigates a physiological phenomenon observed in the peripheral sympathetic nervous system in response to various stressors and tries to bring it closer to clinical research. Sudden surprising stimulation can evoke a transient inhibition of sympathetic nerve activity to blood vessels in the human body which is also predictive of the blood pressure response. READ MORE

  6. 4. Genetic and environmental aspects of symptomatic gallstone disease

    Author : Despina S Katsika; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Gallstone; Swedish Twin Registry; monozygotic; dizygotic; structural equation modeling; body mass index; alcohol; tobacco; ABCG8 D19 H; lith genes; association study;

    Abstract : Gallstone disease (GD) represents a major healthcare problem. Gallstones are likely to result from a complex interaction of the environment and the effects of multiple undetermined genes. READ MORE

  7. 5. Inflammatory bowel disease in twins : studies of genetics and environmental factors

    Author : Jonas Halfvarson; Salvador Peña; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The aetiology of inflammatory bowel disease (IBD) is unknown but considered to be caused by interplay of genetic and environmental factors.The aims of this thesis were to study the influence of genetics and environmental factors in aetiology, disease phenotype and levels of Anti-Saccharomyces cerevisiae antibodies (ASCA), as well as to assess whether CARD15/NOD2 polymorphisms explain the influence of genetics in these aspects. READ MORE