Search for dissertations about: "morpholino"

Showing result 1 - 5 of 14 swedish dissertations containing the word morpholino.

2. 1. Translational research of the quaking gene : Focusing on the conjunction between development and disease

   Author : Bryn Farnsworth; Lina Emilsson; Roman Chrast; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; QKI; glia; oligodendrocyte; Alzheimer s; schizophrenia; zebrafish; statistics; morpholino; Biologi med inriktning mot evolutionär organismbiologi; Biology with specialization in Evolutionary Organismal Biology;

   Abstract : Quaking (QKI) is an RNA binding protein involved in the post-transcriptional regulation of gene expression. Originally identified as the cause of hypomyelination in a mouse mutant, it has since been consistently implicated in a wide range of neurological diseases. READ MORE

4. 2. Glycosaminoglycan Biosynthesis in Zebrafish

   Author : Beata Filipek-Górniok; Lena Kjellén; Johan Ledin; Kay Grobe; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparan sulfate; chondroitin dermatan sulfate; biosynthesis; development; N-deacetylase N-sulfotransferase; glycosyltransferases; morpholino; CRISPR-Cas9;

   Abstract : Proteoglycans (PGs) are composed of highly sulfated glycosaminoglycans chains (GAGs) attached to specific core proteins. They are present in extracellular matrices, on the cell surface and in storage granules of hematopoietic cells. READ MORE

5. 3. Functional genomics of vascular endothelial cells

   Author : Elisabet Wallgard; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Vasculature; endothelial cells; angiogenesis; vascular endothelial growth factor VEGF ; Notch; transcriptome; genomics; microarray; tumor; retina; morpholino knockdown;

   Abstract : Angiogenesis, the formation of new blood vessels from preexisting ones, is a process involved in normal development as well as in several pathological conditions, such as cancer, ischemic heart disease, wound healing and certain retinal complications. Antiangiogenic targeting is therefore a promising new therapeutic principle. READ MORE

6. 4. VEGF-mediated vascular functions in health and disease

   Author : Ziquan Cao; Eric Wahlberg; Yihai Cao; Toste Länne; Kayoko Hosaka; Jack L. Arbiser; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Angiogenesis is essential for physiological processes including embryonic development, tissue regeneration, and reproduction. Under various pathological conditions the same angiogenic process contribute to the onset, development, and progression of many human diseases including cancer, diabetic complications, ocular disease, chronic inflammation and cardiovascular disease. READ MORE

7. 5. Teleost retina : a model for study neurogenesis and angiogenesis

   Author : Satish Srinivas Kitambi; Agneta Mode; Jarema Malicki; Per Kylster; Thomas Burglin; Finn Hallböök; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : Teleost models, zebrafish and medaka have become popular models to study various aspects of developmental biology and genetics. The rapid embryonic development, transparent embryos and the availability of many mutants for various developmental and molecular pathways contribute to the usefulness of these models. READ MORE