Search for dissertations about: "mucosal barrier"

Showing result 1 - 5 of 73 swedish dissertations containing the words mucosal barrier.

  2. 1. Gastrointestinal mucosal protective mechanisms : Mudolatory effects of Heliobacter pyroli on the gastric mucus gel barrier and mucosal blood flow in vivo

    Author : Christer Atuma; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; mucus gel layer; mucosal blood flow; mucus thickness; chronic infection; rat; platelet activating factor; mast cell; nitric oxide; nitric oxide synthase; ketotifen; intra-vital microscopy; microelectrode; laser-Doppler flowmetry; L-NNA; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Abstract : The gastrointestinal mucus gel layer and blood flow are two important mechanisms for protection at the pre-epithelial and sub-epithelial levels, respectively. Helicobacter pylori might circumvent these mechanisms and elicit a chronic inflammatory response with consequent ulcers in the stomach and duodenum. READ MORE

  4. 2. Regulation of Duodenal Mucosal Barrier Function and Motility : The Impact of Melatonin

    Author : Anna Sommansson; Markus Sjöblom; Olof Nylander; Oliver Bachmann; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 51Cr-EDTA; bicarbonate secretion; duodenum; enteric nervous system; enterochromaffin cell; ethanol; hexamethonium; in vivo; mecamylamine; motility; mucosal permeability; parecoxib; rat; Physiology; Fysiologi;

    Abstract : The duodenal mucosa is regularly exposed to acid, digestive enzymes and ingested noxious agents. It is thus critical to maintain a protective barrier to prevent the development of mucosal injury and inflammation, which are often observed in situations when barrier function is impaired. READ MORE

  5. 3. Experimental Disruption of Intestinal Mucosal Homeostasis : Exploring the Protective Potential of Melatonin and Misoprostol

    Author : Karsten Peters; Markus Sjöblom; Hans Lennernäs; David Dahlgren; Åsa Keita; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intestinal barrier dysfunction; intestinal permeability; chemotherapy-induced mucositis; doxorubicin; 5-fluorouracil; apoptosis; proliferation; melatonin; misoprostol; Medicinsk vetenskap; Medical Science;

    Abstract : The intestinal mucosa serves as a protective layer that separates the intestinal contents from the underlying tissues. It restricts harmful substances, pathogens, and undigested particles from entering the bloodstream. READ MORE

  6. 4. Gastrointestinal Permeability and Motility in Inflammatory Bowel Disease

    Author : Anas Kh. Al-Saffar; Per Hellström; Dominic-Luc Webb; Åsa Keita; Uppsala universitet; []
    Keywords : Gastrointestinal motility; intestinal permeability; Mucosal; Ghrelin; Medicinsk vetenskap; Medical Science;

    Abstract : Synchronized motility, permeability and secretory (hormones and enzymes) events are integral to normal physiology. Smooth muscle syncytium operates with enteric nervous system (ENS) and endocrine signalling to accommodate, mix and control passage of ingested materials. READ MORE

  7. 5. The small intestine in experimental peritonitis : An experimental study focusing om intestinal energy metabolism, bacterial translocation and mucosal immunology

    Author : Mikael Ljungdahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Bacterial translocation; endotoxin; faecal peritonitis; high-energy phosphates; hypoxia; intramucosal pH; IL-6; ischaemia; lactate; lymphocytes; mucosal injury; oxygendelivery; pigs; sepsis; tonometry; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : The gut is highly susceptible to injury during sepsis. An impaired mucosal barrier permitstranslocation of enteric microorganisms to blood or other organs. In a porcine model sepsiswas induced by faecal peritonitis. READ MORE