Search for dissertations about: "multivariate design"

Showing result 1 - 5 of 140 swedish dissertations containing the words multivariate design.

  2. 1. Multivariate design of molecular docking experiments : An investigation of protein-ligand interactions

    Author : David Andersson; Anna Linusson Jonsson; Gabriele Cruciani; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular docking; chemometrics; multivariate analysis; principal component analysis; PCA; design of experiments; DoE; partial least-square projections to latent structures; PLS; scoring functions; ligand-binding cavity; major histocompatibility complex; MHC; glycopeptide; T-cell.; Pharmaceutical chemistry; Läkemedelskemi; datorlingvistik; computational linguistics;

    Abstract : To be able to make informed descicions regarding the research of new drug molecules (ligands), it is crucial to have access to information regarding the chemical interaction between the drug and its biological target (protein). Computer-based methods have a given role in drug research today and, by using methods such as molecular docking, it is possible to investigate the way in which ligands and proteins interact. READ MORE

  4. 2. Multivariate Synergies in Pharmaceutical Roll Compaction : The quality influence of raw materials and process parameters by design of experiments

    Author : Nabil Souihi; Johan Trygg; Jukka Rantanen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Roll compaction; dry granulation; mannitol; dicalcium phosphate; design of experiments; orthogonal projections to latent structures; critical quality attributes; tablet manufacturing; quality by design; design space; near-infrared chemical imaging; texture analysis; modeling; scale up; instrumented roll; Johanson model;

    Abstract : Roll compaction is a continuous process commonly used in the pharmaceutical industry for dry granulation of moisture and heat sensitive powder blends. It is intended to increase bulk density and improve flowability. READ MORE

  5. 3. Multivariate methods in tablet formulation

    Author : Jon Gabrielsson; Michael Sjöström; Svante Wold; Torbjörn Lundstedt; Marc Brown; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; PCA; statistical experimental design; multivariate design; PLS; excipients; direct compression; tablet formulation; robustness testing; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : This thesis describes the application of multivariate methods in a novel approach to the formulation of tablets for direct compression. It begins with a brief historical review, followed by a basic introduction to key aspects of tablet formulation and multivariate data analysis. READ MORE

  6. 4. Aspects on probabilistic approach to design : From uncertainties in pre-investigation to final design

    Author : Anders Prästings; Stefan Larsson; Rasmus Müller; Jan Laue; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Reliability-based design; Geotechnical design; Geotechnical structures; Sheet-pile wall; Characterization of uncertainties; Geotechnical investigations;

    Abstract : Geotechnical engineering is strongly associated with large uncertainties. Exploring a medium (soil) that is almost entirely and completely hidden from us is no easy task. Investigations can be made only at discrete points, and the majority of a specific soil volume is never tested. READ MORE

  7. 5. Essays on Sample Surveys : Design and Estimation

    Author : Edgar Bueno; Per Gösta Andersson; Maria Giovanna Ranalli; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; GREG estimator; mixture distribution; probability proportional to size sampling; sampling algorithms; sampling design; sampling strategy; survey sampling; stratified sampling; Statistics; statistik;

    Abstract : Sampling is a core stage in every survey. A sampling design carefully elaborated may imply not only a more accurate estimation of the parameters of interest, but also a reduction in the required sample size in a study. In this thesis we consider two particular but connected subjects. READ MORE