Search for dissertations about: "munc18"

Showing result 1 - 5 of 6 swedish dissertations containing the word munc18.

  2. 1. Role of syntaxin-11 and munc18-2 in lymphocyte cytotoxic granule exocytosis

    Author : Martha-Lena Müller; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mutations in genes required for the exocytosis of cytotoxic granules by NK cells and cytotoxic T lymphocytes are associated with early-onset familial hemophagocytic lymphohistiocytosis (FHL). In this project, we examined how certain missense mutations in genes encoding syntaxin-11 and Munc18-2 abolish exocytosis and cause disease. READ MORE

  4. 2. Molecular mechanisms regulating exocytosis : studies of insulin secretion and neurotransmitter release

    Author : Lena Lilja; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cdk5; cell line; DARPP-32; dephosphorylation; exocytosis; inhibitor-1; insulin; islet; kinase; munc18; myotube; p35; p39; phosphatase; phosphorylation; PP1; presynaptic mechanisms; secretion; subcellular localization.;

    Abstract : In order to achieve normal physiology the secretion of hormones and neurotransmitters needs to be firmly controlled. The basic molecular machinery mediating regulated exocytosis of hormones and neurotransmitters is in principal revealed, but knowledge about how the individual components are spatially and temporarily coordinated is limited. READ MORE

  5. 3. SNAP-25 and Cdk5 as exocytotic regulators : consequences for synaptic function and insulin release

    Author : Jenny Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The process by which cells release substances through fusion of vesicles with the plasma membrane is called exocytosis. Regulated exocytosis needs to be tightly controlled in order to respond to the large variation in stimuli and demands for release of neurotransmitters, peptides and hormones. READ MORE

  6. 4. Components controlling vesicle trafficking and regulated exocytosis in pancreatic beta-cells

    Author : Slavena Andrea Mandic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Regulated exocytosis is a sophisticated, well-organized and conserved multistage process underlying release of both neurotransmitters and hormones. Exocytosis is mediated by SNARE proteins that act at the center stage by forming a SNARE complex with the intrinsic capability to execute membrane fusion. READ MORE

  7. 5. Molecular mechanisms of biphasic insulin secretion

    Author : Nikhil R. Gandasi; Sebastian Barg; Christien Merrifield; Uppsala universitet; []
    Keywords : Exocytosis; Insulin secretion; Membrane trafficking; Microscopy; Diabetes; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Pancreatic beta-cells secrete insulin in response to increase in blood glucose concentration with a rapid first phase and slower, sustained second phase. This secretion pattern is similar in entire pancreas, isolated islets of Langerhans and single beta-cells and it is disrupted in type 2-diabetes. READ MORE