Search for dissertations about: "murine models"
Showing result 1 - 5 of 137 swedish dissertations containing the words murine models.
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1. Lung mechanics and airway inflammation in murine models of asthma
Abstract : Allergic asthma is an inflammatory disease of the airways and is characterized by eosinophilic inflammation and increased airway reactivity. In the studies presented in this thesis, lung mechanics and measurements of airway reactivity were assessed in anaesthetized tracheostomized mice by using an animal ventilator (flexiVent®). READ MORE
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2. Models for infections in immunodeficiency
Abstract : Increased susceptibility to infections in immunodeficient patients is a well-known phenomenon. The spectrum of infections reflects the underlying defect. Experimental infections in mouse strains with different types of defined immunodeficiencies allow studying the course of infectious diseases in immunocompromised hosts. READ MORE
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3. Murine insulin-dependent diabetes mellitus : a model for disease development and protection
Abstract : Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease caused by destruction of the insulin-producing beta cells in the pancreatic Langerhans' islets. This destruction is preceded by an infiltration of mononuclear leukocytes called insulitis. READ MORE
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4. Prostaglandin modulation of airway hyperresponsiveness and inflammation in murine models of asthma
Abstract : Allergic asthma is an inflammatory disease of the airways and is characterised by chronic inflammation, reversible bronchoconstriction and airway hyperresponsiveness (AHR). The cyclooxygenases (COXs) are key enzymes in the biosynthesis of prostaglandins, which have diverse physiological and pathological functions, and are also important modulators of inflammatory responses in the lung. READ MORE
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5. Immune mechanisms in atherosclerosis : the role of T cells in murine models of atherosclerosis
Abstract : Atherosclerosis is an inflammatory disease. Much interest has been focused on the immune responses in the pathogenesis of the disease. The role of T cells in the development of atherosclerosis was therefore investigated in murine models in this study. READ MORE