Search for dissertations about: "mutant"
Showing result 1 - 5 of 940 swedish dissertations containing the word mutant.
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1. Mechanisms controlling striatal projection neurone generation, from patterning to early differentiation
Abstract : The striatum is part of the telencephalon, the most anterior part of the vertebrate brain. From when it first can be identified, telencephalic morphology is highly complex and a wide range of mechanisms has been suggested to participate in its induction, patterning and neurogenesis. READ MORE
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2. Musculoskeletal Development in Jawed Vertebrates : Gene function, cis-regulation, and 3D phenotypes in zebrafish
Abstract : Vertebrate skeletons are an intricate framework of bony and cartilaginous structures that form through carefully orchestrated developmental processes, guided by interacting genetic pathways that regulate cellular differentiation, migration, and tissue morphogenesis. The specific timing and localisation of gene expression shapes the diverse array of skeletal elements, from the flexible cartilages of the embryonic stage to the hardened bones that provide structural support in adulthood, and the joints and connective tissues that articulate the musculoskeletal system. READ MORE
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3. Studies of mutant p53-targeting small molecules
Abstract : Multiple cellular stresses, such as DNA damage, oncogene activation, hypoxia, and telomere erosion induce p53 protein levels leading to an array of biological responses, including cell cycle arrest and apoptosis. p53 exerts its function mainly through transcriptional regulation of specific target genes, but is also able to induce transcriptional-independent apoptosis. READ MORE
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4. Pharmacological targeting of mutant p53 family members
Abstract : The tumor suppressor p53 serves as a guardian of the genome and functions mainly as a transcription factor. In response to various stress signals p53 binds to specific DNA sequence motifs and regulates transcription of a large group of target genes involved in cellular processes such as cell cycle arrest, senescence and apoptosis. READ MORE
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5. Cyanobacterial Hydrogen Metabolism - Uptake Hydrogenase and Hydrogen Production by Nitrogenase in Filamentous Cyanobacteria
Abstract : Molecular hydrogen is a potential energy carrier for the future. Nitrogen-fixing cyanobacteria are a group of photosynthetic microorganisms with the inherent ability to produce molecular hydrogen via the enzyme complex nitrogenase. This hydrogen is not released, however, but is recaptured by the bacteria using an uptake hydrogenase. READ MORE