Search for dissertations about: "mutation accumulation"
Showing result 1 - 5 of 113 swedish dissertations containing the words mutation accumulation.
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1. Wnt/β-Catenin Signalling in Parathyroid Tumours
Abstract : Primary hyperparathyroidism (pHPT) due to parathyroid tumours with hypersecretion of parathyroid hormone and hypercalcaemia is a common disease with incompletely understood etiology affecting more than 1 % of the population, primarily postmenopausal women. In secondary hyperparathyroidism (sHPT), parathyroid tumours develop in response to calcium and vitamin D deficiency generally in patients with uraemia. READ MORE
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2. Mutations and Mutation Rate in the Development of Fluoroquinolone Resistance
Abstract : The emergence of multidrug resistant bacteria world wide is a serious problem, and very few new drugs are under development. The selection of resistant bacteria is affected by factors such as mutation rate, biological fitness cost and the rate of fitness compensation. READ MORE
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3. Full circle : Rise and fate of genetic variation in Marasmius oreades fairy rings
Abstract : Genetic variation is a prerequisite for evolution. The degree of variability within a species is governed by forces including mutation, recombination and selection. READ MORE
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4. New Insights in Genetic and Epigenetic Mechanisms Involved in Parathyroid Tumorigenesis
Abstract : Primary hyperparathyroidism (pHPT) is a pathology associated with one or multiple hyperfunctioning parathyroid glands. The disease prevalence occurs in roughly 1-2% of the population primarily post-menopausal women. The molecular pathology of the disease is poorly understood. READ MORE
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5. Analysis of the Gene and Protein Causing Best Macular Dystrophy
Abstract : Best macular dystrophy (BMD) is an autosomal dominant inherited eye disease with a juvenile onset. Accumulation of the pigment lipofuscin in the retinal pigment epithelium can later cause macular degeneration and loss of vision. READ MORE