Search for dissertations about: "mutation frequency"

Showing result 1 - 5 of 128 swedish dissertations containing the words mutation frequency.

  1. 1. Mutation Analysis and Hypercholesterolemia: Studies in FH patients and in healthy middle-aged men with high, low, or increasing cholesterol levels during a six-year follow-up (the CRISS study)

    University dissertation from Lund University Hospital, S-221 85 Lund, Sweden

    Author : Ulf Ekström; Lunds universitet.; Lund University.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; LDL receptor; Mutation; risk factor; FH; familial hypercholesterolemia;

    Abstract : Our aims were to characterize familial hypercholesterolemia (FH) in a Swedish FH population and to further elucidate the clinical expression and treatment response in relation to genotype. Secondly, we wanted to identify gene variants, which may have impact on cholesterol levels in apparently healthy subjects. READ MORE

  2. 2. Molecular Genetic Alterations In Endometrial And Ovarian Cancers

    University dissertation from Department of Oncology, Clinical Sciences, Lund University

    Author : Anjila Koul; Lunds universitet.; Lund University.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; KRAS; PTEN; TP53; Overexpression; Mutation; Microsatellite instability; Complex atypical hyperplasia; Endometrial cancer; Ovarian cancer; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; CNS metastasis; Cytogenetic analysis; BRCA2; BRCA1; B-catenin; CDKN2A;

    Abstract : Popular Abstract in Swedish Svensk Sammanfattning Gen-förändringar i endometrie- och ovarial cancer: Endometriecancer (EC, cancer i livmoderslemhinnan) är den vanligaste gynekologiska cancerformen i västvärlden. Tumörutvecklingen kan associeras till en östrogen-inducerad stimulans av endometriets tillväxt i avsaknad av den differentierande effekten av progesteron. READ MORE

  3. 3. Development and Stability of Antibiotic Resistance

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Sjölund; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; antibiotic resistance; selection; mutation frequency; biological cost of resistance; compensatory evolution; Helicobacter pylori; normal microbiota; Mikrobiologi; MEDICINE Microbiology; immunology; infectious diseases; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar;

    Abstract : Antibiotic resistance is of current concern. Bacteria have become increasingly resistant to commonly used antibiotics and we are facing a growing resistance problem. The present thesis was aimed at studying the impact of antibiotic treatment on pathogenic bacteria as well as on the normal human microbiota, with focus on resistance development. READ MORE

  4. 4. Biological and Pharmacological Factor that Influence the Selection of Antibiotic Resistance

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ingegerd Gustafsson; Uppsala universitet.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Human microflora; antibiotic resistance; selection; mutation frequency; biological fitness; pharmacokinetics; pharmacodynamics; β-lactam antibiotics; suboptimal dosing regimen; Mikrobiologi; NATURAL SCIENCES Biology Organism biology Microbiology; NATURVETENSKAP Biologi Organismbiologi Mikrobiologi; Klinisk bakteriologi; Clinical Bacteriology;

    Abstract : Antibiotic treatment causes an ecological disturbance on the human microflora. Four commensal bacteria: E. coli, enterococci, a-streptococci and coagulase-negative staphylococci, from patients with extensive, high antibiotic usage were investigated with regard to resistance pattern and mutation frequency. READ MORE

  5. 5. Genetic variability of hepatitis B virus in chronic infection

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Charles Hannoun; Göteborgs universitet.; Gothenburg University.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; mutation; genotype; phylogeny; Recombination; coinfection; interferon; response;

    Abstract : Chronic hepatitis B is a major health problem, and may lead to cirrhosis and hepatocellular carcinoma. The liver damage in hepatitis B virus (HBV) infection is considered to be a result of the immune response, and not a cytopathic effect of the virus itself. READ MORE