Search for dissertations about: "neuronal specification"

Showing result 1 - 5 of 36 swedish dissertations containing the words neuronal specification.

  2. 1. Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2

    Author : Elin Andersson; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; cell replacement; Parkinson?s; dopamine; neuronal specification; development; mesencephalon; TH; neuronal differentiation; proneural genes; transcription factors; bHLH; neurospheres; stem cell; progenitor cell;

    Abstract : Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. READ MORE

  4. 2. The role of Nkx proteins neuronal and glial specification

    Author : Anna Vallstedt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During development, different classes of neurons and glia are generated from proliferative progenitor cells lining the ventricles of the brain and the lumen of the spinal cord. A central issue in developmental neuroscience is to understand the mechanisms by which these cells are generated in space and over time. READ MORE

  5. 3. The Role of miRNA in Neurogenesis and Cell Specification

    Author : Malin Åkerblom; Molekylär neurogenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miRNA; microRNA; miR-124; miR-9; miR-125; adult neurogenesis; neural stem cells; cell specification; microglia; lentiviral vectors; olfactory bulb; olfactory bulb interneurons;

    Abstract : Only a few decades ago, it was generally believed that gene expression was controlled in a unidirectional way, i.e. DNA was transcribed into RNA, which simply acted as a messenger molecule used to produce the protein that executed cellular functions. READ MORE

  6. 4. Neuronal types and their specification dynamics in the autonomic nervous system

    Author : Alessandro Furlan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The autonomic nervous system is formed by a sympathetic and a parasympathetic division that have complementary roles in the maintenance of body homeostasis. Autonomic neurons, also known as visceral motor neurons, are tonically active and innervate virtually every organ in our body. READ MORE

  7. 5. Maintenance of neuronal identity and function

    Author : Konstantinos Toskas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neurons in the CNS acquire specific characteristics throughout development and maintain them for the entire lifespan. Instructive regulation of the transcription machinery ensures the acquisition of identity by spatiotemporal patterns of transcription factor expression. READ MORE