Search for dissertations about: "neurosteroids"

Showing result 1 - 5 of 9 swedish dissertations containing the word neurosteroids.

  2. 1. Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex

    Author : Tobias Johansson; Fred Nyberg; Pierre Le Grevès; Elisabeth Hansson; Uppsala universitet; []
    Keywords : Pharmaceutical pharmacology; Pharmacology; neurosteroids; NMDA receptor; NR2B subunit; ifenprodil; sigma receptor; anabolic androgenic steroids; allosteric modulation; non-genomic; Farmaceutisk farmakologi;

    Abstract : The neurosteroids constitute a group of powerful hormones synthesized and acting in the central nervous system. They participate in a number of important central processes, such as memory and learning, mood and neuroprotection. READ MORE

  4. 2. Ovarian hormones and effects in the brain : studies of neurosteroid sensitivity, serotonin transporter and serotonin2A receptor binding in reproductive and postmenopausal women

    Author : Anna-Carin Wihlbäck; Tord Naessén; Umeå universitet; []
    Keywords : estradiol; progesterone; progestin; neurosteroids; saccadic eye velocity; sedation; hormone replacement therapy HRT ; menopause; menstrual cycle; mood; serotonin; paroxetine; lysergic acid diethylamide; platelets; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background: Estrogen has been reported to enhance well-being and quality of life during the climacteric phase. In women with an intact uterus estrogen treatment is always combined with progestins in order to protect the endometrium from hyperplasia and malignancies. READ MORE

  5. 3. Nano-electrospray mass spectrometry for the analysis of neurosteroids and related molecules

    Author : Suya Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neurosteroids are steroids synthesised in the central and peripheral nervous systems. Known neurosteroids include pregnenolone, dehydroepiandrosterone (DHEA), progesterone and its reduced metabolites. READ MORE

  6. 4. Progesterone metabolites : learning, tolerance, antagonism & metabolism

    Author : Charlotte Öfverman; Inga-Maj Johansson; Torbjörn Bäckström; Esa Korpi; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allopregnanolone; isoallopregnanolone; THDOC; learning; tolerance; antagonism; inhibition; patch clamp; Morris water maze; metabolism; epimerization; Obstetrics and gynaecology; Obstetrik och gynekologi; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Progesterone metabolites as allopregnanolone, isoallopregnanolone and tetrahydrodeoxy-corticosterone (THDOC) are increased in the luteal phase of the menstrual cycle, throughout pregnancy and during stress. Allopregnanolone and THDOC are neurosteroids with 3α-hydroxy, 5α-configurations and positive modulating effect on the GABAA receptor. READ MORE

  7. 5. Behavioral effects of female sex steroid hormones : models of PMS and PMDD in Wistar rats

    Author : Magnus Löfgren; Torbjörn Bäckström; Inga-Maj Johansson; Per Södersten; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; PMS; PMDD; rats; progesterone; estradiol; behavior; individual response; stress interaction; tolerance; withdrawal; learning and memory; anxiety.; Biological research on drug dependence; Biologisk beroendeforskning; Endocrinology; Endokrinologi; Obstetrics and gynaecology; Obstetrik och gynekologi; Pharmacological research; Farmakologisk forskning; Obstetrics and gynaecology; Obstetrik och gynekologi; Psychology; Psykologi; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background Animal models can be used to mimic human conditions of psychopathology, and also as pre-clinical models to evaluate candidate drugs. With hormonal treatment it is possible to produce behavior in the rat which corresponds to the mental symptoms of pre-menstrual syndrome (PMS), and pre-menstrual dysphoric disorder (PMDD). READ MORE