Search for dissertations about: "neutralizing antibodies"

Showing result 1 - 5 of 110 swedish dissertations containing the words neutralizing antibodies.

  2. 1. Effects of galectins and antibodies in HIV infection; Novel Assays

    Author : Enas Sheik-Khalil; Institutionen för laboratoriemedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; galectin-1; galectin-8; neutralizing antibodies; cell-cell fusion; Microscale anisotropy assay; virus binding assay; glycosylation; gp120; Automated plaque reduction assay; CellProfiler; NeutNet;

    Abstract : The high variability of the HIV envelope glycoproteins (Env), and their heavy glycan coating, contributes to the limited host immune control. Still, broadly neutralizing antibodies (bnAbs) are found in some chronically infected HIV-infected individuals, which has spurred the research on antibody-based vaccines. READ MORE

  4. 2. Immunological characteristics of recombinant fragments of the Plasmodium falciparum blood-stage antigen Pf332

    Author : Halima A. Balogun; Klavs Berzins; Lars Hviid; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Plasmodium falciparum; Pf332; antibodies; immunity; growth inhibition; Immunology; Immunologi; immunologi; Immunology;

    Abstract : Effective malaria vaccine might help improve control strategies against malaria, but the complexity of interactions between the parasite and its hosts poses challenges. The asexual blood stage P. falciparum antigen Pf332 has potentials as one of the proteins in understanding the complex host-parasite interactions. READ MORE

  5. 3. Interferon-beta treatment in multiple sclerosis : analysis of neutralizing antibodies

    Author : Ajith Sominanda; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is a disabling chronic neurological disease with a significant impact on patients lives. There is no cure for MS, but recombinant interferon beta (IFN-beta) is currently the most established disease modifying therapy. READ MORE

  6. 4. Evaluation of new strategies to elicit neutralizing antibodies against HIV-1

    Author : Mattias Forsell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The development of an effective HIV-1 vaccine must be considered one of the greatest biomedical challenges of today. The nature of the virus, characterized by immense variability as well as its tropism for the essential CD4+ T cells of the immune system, allows it to establish a chronic infection for years under constant immune selection pressure. READ MORE

  7. 5. Studies on Potency and breadth of HIV-1, HIV-2 and SIV neutralizing antibody responses

    Author : Gülsen Özkaya Sahin; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; HIV-2; SIV; envelope; neutralizing antibody; breadth; potency; IgG; IgA; complement; antibody-dependent complement-mediated inactivation; virus evolution; diversity; divergence;

    Abstract : Even though the relative contribution of neutralizing antibodies (Nab) to prevent progression to AIDS during HIV-1 infection is still unclear, the induction of broadly NAb directed against HIV-1 through vaccination is considered to represent an important goal for the development of HIV-1 vaccines. Factors contributing to the induction of NAb may include the strength and duration of antigenic stimulation, the preservation of CD4+ T and B cells, the conformation of the HIV-1 envelope glycoprotein complex (Env), and the evolution of Env during infection. READ MORE