Search for dissertations about: "nitrotyrosine"

Showing result 1 - 5 of 13 swedish dissertations containing the word nitrotyrosine.

2. 1. A qualitative and quantitative study of nitrotyrosine using mass spectrometry and immunochemistry

   Author : Ann-Sofi Söderling; Göteborgs universitet; []
   Keywords : mass spectrometry; oxidative stress; nitrotyrosine; nitric oxide; protein modification;

   Abstract : Background: Reactive oxygen (ROS), and nitrogen (RNS) species are formed during normal metabolism and in higher concentration in pathological conditions. They may cause cellular damage when the antioxidant defence is unable to balance the production of oxidants. READ MORE

4. 2. Mass spectrometric investigation of protein nitration in inflammation and neurodegeneration

   Author : Henrik Ryberg; Göteborgs universitet; []
   Keywords : mass spectrometry; oxidative stress; nitrotyrosine; neurodegeneration; peroxynitrite; protein modification;

   Abstract : The nitration of tyrosine seems to be very common in human diseases and at least forty different diseases have been reported to be associated with an increased nitration of proteins. The nitration of proteins results in a modification of tyrosine, 3-nitrotyrosine (3-NT), which is stable. READ MORE

5. 3. Helicobacter pylori associated effects on inflammatory radical formation and angiotensin II receptors in the stomach

   Author : Anders Elfvin; Göteborgs universitet; []
   Keywords : Helicobacter pylori; Mongolian gerbil; gastric adenocarcinoma; nitro-radical; iNOS; nitric oxide; nitrotyrosine; oxy-radical; myeloperoxidase; angiotensin II; AT1R; AT2R;

   Abstract : Helicobacter pylori infection of the stomach always results in mucosal inflammation and a marked systemic immune response. Despite the profound host defence reactions the bacterium avoids elimination and persists in the mucosa. This results in chronic inflammation and an increased risk for peptic ulcers and adenocarcinoma. READ MORE

6. 4. Inducible nitric oxide synthase in experimental urinary tract infection

   Author : Mirjana Poljakovic; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; host defense; cell viability; nitrate; lipopolysaccaride; cytokines; sphingomyelinase; mitogen activator protein kinase; nitric oxide; nitrotyrosine; E. coli; cyclooxygenase; urinary tract infection; prostaglandins; urothelium; bladder; kidney; NADPH diaphorase histochemistry; nitric oxide synthase; vävnadskultur; histokemi; cytokemi; Histologi; tissue culture; histochemistry; cytochemistry; Histology; nefrologi; Urologi; nephrology; Infections; Infektioner;

   Abstract : Urinary tract infection (UTI) is among the most common bacterial infections in humans and the majority are caused by Escherichia coli (E. coli). Abundant evidence indicates that nitric oxide (NO) produced by the inducible NO synthase (iNOS) plays an important role in host defense against infection. READ MORE

7. 5. Exhaled markers of oxidative stress in the airways

   Author : Mona Lärstad; Göteborgs universitet; []
   Keywords : exhaled air; exhaled breath condensate; malondialdehyde; 3-nitrotyrosine; ethane; pentane; isoprene; oxidative stress; airways; inflammation;

   Abstract : Breath contains a number of different molecules, some of which may have potential use as markers for oxidative stress in the airways during chronic airway inflammation. The major objectives were to develop and validate methods for quantifying five potential exhaled markers of oxidative stress: malondialdehyde (MDA) and free 3-nitrotyrosine (3-NT) in exhaled breath condensate (EBC) and ethane, pentane and isoprene in exhaled air, and to test the applicability of the methods. READ MORE