Search for dissertations about: "non-covalent interaction"

Showing result 1 - 5 of 13 swedish dissertations containing the words non-covalent interaction.

  1. 1. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase

    University dissertation from Umeå : Umeå universitet

    Author : Lotta Berg; Umeå universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; drug discovery; density functional theory; hydrogen bond; nerve-agent antidote; non-covalent interaction; protein-ligand complex; structure-based design; thermodynamics; X-ray crystallography; läkemedelskemi; läkemedelskemi;

    Abstract : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. READ MORE

  2. 2. Identification and Characterization of Peptides and Proteins using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Magnus Palmblad; Uppsala universitet.; [2002]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Materials science; Peptide; protein; peptide mass fingerprinting; identification; sequencing; protein structure; non-covalent interaction; modification; electrospray ionization; liquid chromatography; capillary electrophoresis; electron capture dissociation; Fourier transform ion cyclotron resonance mass spectrometry; cerebrospinal fluid; amyloid β-peptide; Alzheimer’s disease.; Materialvetenskap; TECHNOLOGY Materials science; TEKNIKVETENSKAP Teknisk materialvetenskap; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Mass spectrometry has in recent years been established as the standard method for protein identification and characterization in proteomics with excellent intrinsic sensitivity and specificity. Fourier transform ion cyclotron resonance is the mass spectrometric technique that provides the highest resolving power and mass accuracy, increasing the amount of information that can be obtained from complex samples. READ MORE

  3. 3. Studies on the Non-covalent Interactions (Stereoelectronics, Stacking and Hydrogen Bonding) in the Self-assembly of DNA and RNA

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Parag Acharya; Uppsala universitet.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; nucleic acids; NMR; Stereoelectronic effects; Hydrogen Bonding; Stacking; Bioorganisk kemi; NATURAL SCIENCES Chemistry Organic chemistry Bioorganic chemistry; NATURVETENSKAP Kemi Organisk kemi Bioorganisk kemi;

    Abstract : This thesis is based on ten publications (Papers I-X). The phosphodiester backbone makes DNA or RNA to behave as polyelectrolyte, the pentose sugar gives the flexibility, and the aglycones promote the self-assembly or the ligand-binding process. READ MORE

  4. 4. Separation of Proteins with Capillary Electrophoresis in Coated Capillaries with and without Electroosmosis Studies on Zone Broadening and Analytical Performances

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sheila Mohabbati; Uppsala universitet.; [2006]
    Keywords : Pharmaceutical chemistry; Capillary electrophoresis; capillary coatings; proteins; zone broadening; zone sharpening; efficiency; resolution; protein-surface adsorption; protein-buffer interaction; analytical performance; Farmaceutisk kemi;

    Abstract : Proteins have such structural features that they may interact with different types of surfaces by all possible forces, i.e., electrostatic, hydrogen bonding, hydrophobic. In this thesis two different types of coatings for fused silica capillaries aimed to eliminate such interactions have been studied. READ MORE

  5. 5. Hydrogels of conjugated polyelectrolytes for biosensor and biochip applications

    University dissertation from Linköping : Linköpings universitet

    Author : Peter Åsberg; Linköpings universitet.; Linköpings universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : This thesis describes the use of conjugated polyelectrolytes (CPEs) in biosensor devices. The method is based on non-covalent assembly of the biomolecule of interest and the CPE functioning as the reporter, in one case as a transducer, of biomolecular events. READ MORE