Search for dissertations about: "non-nucleoside inhibitor"

Showing result 1 - 5 of 12 swedish dissertations containing the words non-nucleoside inhibitor.

  1. 1. Biosensor Studies of Ligand Interactions with Structurally Flexible Enzymes Applications for Antiviral Drug Development

    University dissertation from Uppsala : Institutionen för naturvetenskaplig biokemi

    Author : Matthis Geitmann; Uppsala universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR biosensor; HIV-1 reverse transcriptase; HCMV protease; interaction kinetics; drug discovery; non-nucleoside inhibitor; resistance; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : The use of a surface plasmon biosensor fills a missing link in kinetic studies of enzymes, since it measures directly the interaction between biomolecules and allows determination of parameters that are determined only indirectly in activity assays. The present thesis deals with kinetic and dynamic aspects of ligand binding to two viral enzymes: the human cytomegalovirus (HCMV) protease and the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). READ MORE

  2. 2. Structure-aided design of antiviral drugs : Application of the method on HIV-1 protease and SIV reverse transcriptase

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hans Ola Andersson; Uppsala universitet.; [1999]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; HIV; protease; SIV; reverse transcriptase; structure; inhibitor; drug design; Utvecklingsbiologi; NATURAL SCIENCES Biology Organism biology Developmental biology; NATURVETENSKAP Biologi Organismbiologi Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Many efforts have been made to control the AIDS epidemic. Extensive studies have been done on the biology, biochemistry, and structural biology of HIV in the search for antiviral drugs. The viral-encoded enzymes reverse transcriptase and protease have been main targets for drug design. READ MORE

  3. 3. HIV-1 reverse transcriptase activity assays based on monoclonal antibodies to native enzyme : Applications on studies of antiviral substances and immunological variation of reverse transcriptase

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ann-Sofie Rytting; Uppsala universitet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; HIV-1; reverse transcriptase; monoclonal antibody; activity assay; subtype; RT inhibitor; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; medicinsk genetik; Medical Genetics;

    Abstract : Specific detection of HIV-1 reverse transcriptase (RT) activity in crude materials was enhanced using a capture assay for immunopurification and subsequent activity assay. The purification step was achieved by anti-HIV-1 RT monoclonal antibodies (Mabs) immobilized onto a solid carrier. READ MORE

  4. 4. Structure-Assisted Design of Drugs Towards HIV-1 and Malaria Targets Applied on Reverse Transcriptase and Protease from HIV-1 and Plasmepsin II from Plasmodium falciparum

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jimmy Lindberg; Uppsala universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; X-ray crystallography; Drug design; HIV-1; Malaria; Molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi;

    Abstract : Globally of today, acquired immunodeficiency syndrome (AIDS) and malaria are two of the most threatening diseases known to mankind. The World Health Organization estimated that AIDS and malaria together claimed nearly 4 million lives in 2003 and many more were infected by the causative agent human immunodeficiency virus (HIV) and the Plasmodium falciparum (P. READ MORE

  5. 5. Kinetic studies of NS3 and NS5B from Hepatitis C virus Implications and applications for drug discovery

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Göran Dahl; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; NS3; NS5B; enzyme kinetics; inhibition; resistance; drug; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi; Biokemi; Biochemistry;

    Abstract : The aim of these studies was to increase our understanding of the non-structural proteins 3 and 5B (NS3 and NS5B) from the hepatitis C virus (HCV), and thereby contribute to the development of new and better drugs against HCV.By studying NS3 with substitutions identified to be associated with resistance to NS3 inhibitors in clinical trials (R155Q, A156T and D168V) it was found that not all inhibitors were affected, indicating that cross-resistance can be avoided. READ MORE