Search for dissertations about: "non-targeted screening"

Showing result 1 - 5 of 7 swedish dissertations containing the words non-targeted screening.

  2. 1. Toxicometabolomics and biotransformation product screening in single zebrafish embryos

    Author : Anton Ribbenstedt; Jonathan P. Benskin; Magnus Breitholtz; Elena Gorokhova; Emma Schymanski; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Non-target; REACH; Orbitrap; single embryo; zebrafish embryo; metabolism; high throughput; hydroxylation; glucuronidation; metabolite screening; phase I; phase II; pharmaceutical; structure elucidation; conjugation; propranolol; beta blocker; Non-targeted; toxicometabolomics; Orbitrap; single embryo; 3R; metabolomics; MoA; mode of action; zebrafish embryo; carbamazepine; biotransformation; Applied Environmental Science; tillämpad miljövetenskap;

    Abstract : Over the last decade environmental agencies worldwide have escalated their work to phase out animal testing for the purposes of chemical regulation. Meanwhile the number of commercially available chemicals and the requirements for hazard assessments have both increased, creating a large need for substitution of traditional in vivo assays with in vitro tests. READ MORE

  4. 2. Removal processes in sewage treatment plants : Sludge quality and treatment efficiency of structurally diverse organic compounds

    Author : Ulrika Olofsson; Peter Haglund; Staffan Lundstedt; Juliane Hollender; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Environmetrics; flame retardants; GCxGC; non-targeted screening; mass flow; metals; plasticizers; poorly removed contaminants; POP; PPCP; prediction; Principal Component Analysis; removal efficiency; sewage; sewage treatment plants; sludge; sludge adsorption; sources; time-trend analysis; Environmental chemistry; Miljökemi;

    Abstract : Large and ever-increasing numbers of chemicals, including large quantities of a broad spectrum of organic compounds are used in modern society. More than 30 000 of the more than 100 000 chemical substances registered in the EU are estimated to be daily used, of which many will be discharged into the waste-streams handled by municipal sewage treatment plants (STPs). READ MORE

  5. 3. Methods for structural studies of an antibody, screening metabolites in rat urine and analysis of spent cell cultivation media using LC/ESI-MS and chemometrics

    Author : Leila Zamani; Sven P. Jacobsson; Jonas Bergqvist; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Screening; Fingerprinting; metabolomics; Protein drugs; Mammalian Cell lines; LC ESI-MS; chemometrics; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Abstract : This thesis describes bioanalytical methods for generating fingerprints of biological systems for extracting relevant information with (protein) drugs in focus. Similarities and differences between samples can reveal the hidden relevant information, which can be used to optimize the production and facilitate the quality control of such protein drugs during their development and manufacture. READ MORE

  6. 4. Chemicals in textiles : A potential source for human exposure and environmental pollution

    Author : Giovanna Luongo; Conny Östman; Peter Haglund; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical Chemistry; analytisk kemi;

    Abstract : The wide use of chemicals in textile production is common knowledge, whilst very little has been done to disclose the potentially harmful compounds hiding in our closet. The initial part of this work focused on explorative screening of textile materials in common clothing. READ MORE

  7. 5. Multi-platform metabolomics assays to study the responsiveness of the human plasma and lung lavage metabolome

    Author : Masoumeh Karimpour; Malin Nording L.; Magnus Åberg; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LC MS; GC MS; NMR; metabolomics; metabolite; exposure; postprandial; plasma; lung lavage; BW; BW; data analysis; univariate analysis; multivariate analysis;

    Abstract : Metabolomics as a field has been used to track changes and perturbations in the human body by investigating metabolite profiles indicating the change of metabolite levels over time and in response to different challenges. In this thesis work, the main focus was on applying multiplatform-metabolomics to study the human metabolome following exposure to perturbations, such as diet (in the form of a challenge meal) and exhaust emissions (air pollution exposure in a controlled setting). READ MORE