Search for dissertations about: "nucleoside kinase"

Showing result 1 - 5 of 39 swedish dissertations containing the words nucleoside kinase.

  2. 1. Studies on nucleoside diphosphate kinase

    Author : Bror Edlund; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 2. Structure determination of Methanocaldococcus jannaschii nucleoside kinase

    Author : Linda Arnfors; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Methanocaldococcus jannaschii; Archaea; hyperthermophile; nucleoside kinase; ribokinase family; X-ray crystallography; differential scanning calorimetry; thermal stability;

    Abstract : All organisms can be divided into the tree kingdoms of life: Archaea, Bacteria and Eukarya. Archaeal organisms are often found to exhibit, compared to human perspectives, extreme environments, such as high temperature, high salt and acidic habitats. Many archaeal species are hyperthermophiles, i.e. READ MORE

  5. 3. Deoxyribonucleoside kinases in bacteria, plants and humans

    Author : Anders Ranegaard Clausen; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; anti-viral drugs; gene therapy; cancer; evolution; nucleoside analog; deoxyribonucleoside kinase; thymidine kinase;

    Abstract : Deoxyribonucleoside triphosphates (dNTPs) are the building blocks of DNA and can be synthesized either de novo or via salvage pathways. The first reaction in the salvage pathway of dNTPs is the conversion of deoxyribonucleosides (dN) into the deoxyribonucleoside monophosphate (dNMP). READ MORE

  6. 4. Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei

    Author : Munender Vodnala; Anders Hofer; Arne Holmgren; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Trypanosoma brucei; adenosine kinase; thymidine kinase; methylthioadenosine phosphorylase; mouser ribonucleotide reductase; E. coli ribonucleotide reductase; RNR; Ara-A; F-Ara-A; dNTP; NTP; doexynucleotide metabolism; nucleosides; nucleoside kinases; allosteric regulation; biologisk kemi; biological chemistry;

    Abstract : Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs.T. READ MORE

  7. 5. Pharmacology and resistance mechanisms of nucleoside analogues and topoisomerase II interactive agents : studies on human leukemia cells with a focus on cross-resistance

    Author : Kourosh Lotfi; Rolf Larsson; Linköpings universitet; []
    Keywords : Nucleoside analogue; cross-resistance; multidrug resistance; deoxycytidine kinase; leukemia; anthracyclines; P-glycoprotein; MEDICINE; MEDICIN;

    Abstract : The purpose of this thesis was to elucidate mechanisms of action and resistance of clinically relevant nucleoside analogues and topoisomerase interactive agents in human leukemia cell lines and leukernia cells isolated from peripheral blood of leukemia patients. Interactions and cross-resistance patterns of these different cytotoxic drug families were also studied since these drugs are usually administrated in combination in the clinic. READ MORE