Search for dissertations about: "onkologi"

Showing result 11 - 15 of 993 swedish dissertations containing the word onkologi.

2. 11. Radiosensitivity in lung cancer with focus on p53

   Author : Michael Bergqvist; Claes Mercke; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Lung cancer; comet assay; p53; cDNA; p53 antibodies; Lungcancer; Komet metoden; p53 antikroppar; Onkologi; Oncology; Onkologi; Oncology; onkologi;

   Abstract : In Sweden approximately 2800 new lung cancer patients are diagnosed every year. Radiotherapy is used with curative intention in certain groups of patients. The aim of this thesis is to study the basis of differences in radioresistance and the possibility to predict response to radiotherapy. READ MORE

4. 12. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response

   Author : Fredrik Qvarnström; Ingela Turesson; Gunilla Enblad; Mats Harms-Ringdahl; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; γH2AX; 53BP1; checkpoint; p21; apoptosis; mitosis; Oncology; Onkologi; Oncology; onkologi;

   Abstract : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. READ MORE

5. 13. Vaccine Therapy of Colorectal Cancer Patients with Tumor Associated Antigens

   Author : Gustav Ullenhag; Håkan Mellstedt; Carl Magnusson; Bengt Glimelius; Torgny Stigbrand; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Oncology; Colorectal cancer; GM-CSF; vaccination; CEA; ALVAC-KSA; IgG subclass; epitopes; Onkologi; Oncology; Onkologi; Oncology; onkologi;

   Abstract : In this thesis, two different vaccines were evaluated as adjuvant therapy for patients with colorectal cancer. The ability of the two candidate vaccines to generate antigen-specific cellular and humoral responses, respectively, was studied. READ MORE

6. 14. Investigations of Leucine-rich repeats and immunoglobulin-like domain-proteins 1 and 2 (LRIG1 and LRIG2) and their genes in cancer

   Author : Mahmood Faraz; Håkan Hedman; Roger Henriksson; Rolf Bjerkvig; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LRIG1; LRIG2; PDGFR; glioma; interactome; breast cancer; prognosis; Oncology; onkologi;

   Abstract : The mammalian leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family consists of three different members, LRIG1, LRIG2, and LRIG3. These genes are expressed in all human and mouse tissues analyzed to date. READ MORE

7. 15. Molecular and Biological Characteristics of Stroma and Tumor Cells in Colorectal Cancer

   Author : Jingfang Gao; Xiao-Feng Sun; Richard Palmqvist; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carcinogenesis; genetic alterations; colorectal cancer CRC ; cysteine-histidine rich protein PINCH ; Inflammatory infiltration; Angiogenesis; lymphangiogenesis; Oncology; Onkologi;

   Abstract : Carcinogenesis is a progressive process involving multiple genetic alterations in tumor cells and complex interactions in the tumor-host microenvironment. To better understand the contribution of molecular alterations in tumor cells and stromal variables to the development of colorectal cancer (CRC) and identify prognostic factors, in this study we examined the clinicopathological and biological significance of stromal variables, including particularly interesting new cysteine-histidine rich protein (PINCH), inflammatory infiltration, angiogenesis and lymphangiogenesis, as well as hRAD50/hMRE11/hNBS1 proteins and hRAD50 mutation in tumor cell in CRC. READ MORE