Search for dissertations about: "opioid peptide"

Showing result 1 - 5 of 37 swedish dissertations containing the words opioid peptide.

2. 1. Quantitative Aspects of Nanodelivery Across the Blood-Brain Barrier : Exemplified with the Opioid Peptide DAMGO

   Author : Annika Lindqvist; Margareta Hammarlund-Udenaes; Markus Fridén; William Elmquist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blood-brain barrier; liposomes; nanocarriers; brain delivery; pharmacokinetics; modeling and simulation; microdialysis; opioid peptide; DAMGO; LC-MS MS; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : The use of nanocarriers is an intriguing approach in the development of efficacious treatment for brain disorders. The aim of the conducted research was to evaluate and quantify the impact of a liposomal nanocarrier formulation on the brain drug delivery. READ MORE

4. 2. The opioid peptide dynorphin A : Biophysical studies of peptide–receptor and peptide–membrane interactions

   Author : Johannes Björnerås; Lena Mäler; Astrid Gräslund; Scott Prosser; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; dynorphin A; opioid receptor; neuropeptide; bicelles; NMR; diffusion; decomposition; Biophysics; biofysik;

   Abstract : The work presented in this thesis concerns the opioid peptide dynorphin A (DynA). DynA functions primarily as a neurotransmitter and belongs to the family of typical opioid peptides. These peptides are a part of the opioid system, together with the opioid receptors, a family of GPCR membrane proteins. READ MORE

5. 3. Evolution of the Neuropeptide Y and Opioid Systems and their Genomic Regions

   Author : Görel Sundström; Dan Larhammar; Manfred Schartl; Uppsala universitet; []
   Keywords : neuropeptide Y; opioid; evolution; genome duplication; gene duplication; Hox; SCN; IGFBP; MEDICINE; MEDICIN;

   Abstract : Two whole genome duplications (2R) occurred early in vertebrate evolution. By using combined information from phylogenetic analyses and chromosomal location of genes, this thesis delineates the evolutionary history of two receptor-ligand systems that expanded by these large scale events. READ MORE

6. 4. Levodopa- and Neuroleptic-Induced Dyskinesias : Studies on Pharmacological Modification and Processing of Opioid Neuropeptides

   Author : Rebecka Klintenberg; Alan Crossman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Opioid peptides; dyskinesia; Parkinson s disease; mass spectrometry; metabolism; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning; biologisk beroendeforskning; Biological Research on Drug Dependence;

   Abstract : Dyskinesias or abnormal involuntary movements are a debilitating complication of long-term levodopa treatment of Parkinson’s disease (PD) that is widely experienced and may compromise the efficacy of the drug therapy. Tardive dyskinesia is another important adverse effect seen with antipsychotic drug treatment. READ MORE

7. 5. Hemorphins and endomorphins

   Author : Katarina Sanderson Nydahl; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Hemorphins; endomorphins; opioid receptors; peptide metabolism; neurogenic inflammation; pain; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; biologisk beroendeforskning; Biological Research on Drug Dependence;

   Abstract : In this thesis, two newly discovered endogenous opioid peptide families, the hemorphins and endomorphins, are investigated with emphasis on modulation of pain and inflammation. In addition, the presence of hemorphins in human biological fluids as well as the in vitro and in vivo processing ofLVV-hemorphin-7 in blood and brain is investigated. READ MORE