Search for dissertations about: "osteoclast differentiation"

Showing result 1 - 5 of 19 swedish dissertations containing the words osteoclast differentiation.

  2. 1. CD47–SIRPα : an interaction of importance for bone cell differentiation

    Author : Cecilia Koskinen; Pernilla Lundberg; Per-Arne Oldenborg; Riku Kiviranta; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD47; SIRPalpha; osteoblast; osteoclast; SHP-2; Akt2; cell research; cellforskning;

    Abstract : Bone tissue is continuously remodeled by bone-forming osteoblasts and bone-resorbing osteoclasts, in processes tightly regulated by hormones, cytokines and growth factors. CD47, a ubiquitously expressed protein, and one of its ligands, signal-regulatory protein alpha (SIRPα), are two cell-surface proteins belonging to the immunoglobulin (Ig)-superfamily. READ MORE

  4. 2. Effects of silicon on bone. Clinical observations and experimental cell studies

    Author : Catarina Magnusson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; silicon; osteoclast; pregnancy; lactation; bone metabolism; bone regeneration;

    Abstract : Bone health has a major impact on life quality. In Sweden, osteoporosis is a highly prevalent skeletal disease that primarily affects the elderly, causing fragility fractures and pain. READ MORE

  5. 3. Toll-like receptors (TLRs) and inflammatory bone modeling

    Author : Ali Kassem; Ulf Lerner; Pernilla Lundberg; Pedro Souza; Timothy Arnett; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toll-like receptor; osteoclast; osteoblast; bone resorption; bone formation; P. gingivalis; S. aureus; flagellin.;

    Abstract : Patients with inflammatory or infectious conditions such as periodontitis, peri-implantitis, osteomyelitis, rheumatoid arthritis, septic arthritis and loosened joint prosthesis display varying severity of destruction in the adjacent bone tissue. Bone loss in inflammatory diseases is considered a consequence of cytokine induced RANKL and subsequent enhanced osteoclast formation. READ MORE

  6. 4. Novel Insights into Inflammatory Disturbed Bone Remodelling

    Author : Elin Kindstedt; Pernilla Lundberg; Östen Ljunggren; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone; osteoblast; osteoclast; chemokines; CCL11; periodontitis; rheumatoid arthritis; innate lympoid cells; odontologi; Odontology; immunologi; Immunology; biology; biologi; reumatologi; rheumatology;

    Abstract : Bone is a dynamic tissue that is continuously remodelled, a process that requires equal amounts of osteoclastic bone resorption and osteoblastic bone formation. Inflammation may disturb the equilibrium and result in local and/or systemic bone loss. Negative bone mass balance occurs in several chronic inflammatory diseases, e.g. READ MORE

  7. 5. The calcitonin gene family of peptides : receptor expression and effects on bone cells

    Author : Susanne Granholm; Ulf Lerner; Pernilla Lundberg; Göran Andersson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; CT family of peptides; osteoclast differentiation; bone resorption; CTR; CRLR; RAMPs; Cell biology; Cellbiologi;

    Abstract : The calcitonin gene family of peptides consists of calcitonin (CT), two calcitonin gene related peptides (α-CGRP, β-CGRP), adrenomedullin (ADM), amylin (AMY), three calcitonin receptor activating peptides (CRSP1-3) and intermedin/adrenomedullin2 (IMD). These peptides bind to one of two G protein -coupled receptors, the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CRLR). READ MORE