Search for dissertations about: "oxidative stress in experimental diabetes"

Showing result 1 - 5 of 11 swedish dissertations containing the words oxidative stress in experimental diabetes.

2. 1. Experimental and Clinical Studies of Oxidative Stress in Pre-Eclampsia

   Author : Peppi Nash; Ulf Eriksson; Matts Olovsson; Leif Jansson; Lucilla Poston; Uppsala universitet; []
   Keywords : Obstetrics and gynaecology; Pre-eclampsia; Oxidative stress; Diabetes; Placenta; Rat; Antioxidants; Suramin; Vitamin E; Vitamin C; PAI-1; PAI-2; Obstetrik och kvinnosjukdomar;

   Abstract : Impaired placentation and oxidative stress are proposed to play major roles in the pathogenesis of pre-eclampsia (PE). It has recently been pointed out that PE might be more than one disease and may have several different pathogeneses. READ MORE

4. 2. Teratogenic Predisposition in Diabetic Rat Pregnancy

   Author : Andreas Ejdesjö; Ulf J Eriksson; Parri Wentzel; Niklas Nordquist; Gernot Desoye; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; malformations; teratogenic; advanced glycation end products; AGE; RAGE; oxidative stress; ROS; gene expression; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : Pre-gestational diabetes increases the risk of congenital malformation in the offspring and both morbidity and mortality in the diabetic mother and her offspring. During pregnancy, high glucose levels act as a teratogen through several cellular and biochemical pathways and increased production of reactive oxygen species (ROS) has a central role in diabetic embryopathy. READ MORE

5. 3. Aspects of Regulation of GFR and Tubular Function in the Diabetic Kidney : Roles of Adenosine, Nitric Oxide and Oxidative Stress

   Author : Patrik Persson; Fredrik Palm; Peter Hansell; Bengt Rippe; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; diabetic nephropathy; glomerular filtration rate; renal blood flow; insulin; renal hemodynamics; micropuncture; oxygen; NADPH-oxidase; apocynin; streptozotocin; l-arginine; CGS21680; rats; mice; Physiology; Fysiologi; Medical Science; Medicinsk vetenskap;

   Abstract : Diabetic nephropathy is the main cause for initiation of renal replacement therapy and early symptoms in patients include increased glomerular filtration rate (GFR), decreased oxygen tension and albuminuria, followed by a progressive decline in GFR and loss of kidney function. Experimental models of diabetes display increased GFR, decreased tissue oxygenation and nitric oxide bioavailability. READ MORE

6. 4. Oxidative stress, antioxidative defence and outcome of gestation in experimental diabetic pregnancy

   Author : Jonas Cederberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pregnancy; rat; ROS; free oxygen radicals; TBARS; isoprostanes; protein carbonyls; embryo; vitamin C; vitamin E; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Abstract : Maternal type 1 diabetes is associated with an increased risk for foetal malformations. The mechanism by which diabetes is teratogenic is not fully known. Previous studies have demonstrated that radical oxygen species can contribute to the teratogenicity of glucose and diabetes. READ MORE

7. 5. Teratogenicity Involved in Experimental Diabetic Pregnancy

   Author : Mattias Gäreskog; Parri Wentzel; Ulf Eriksson; Jonas Cederberg; Kari Teramo; Uppsala universitet; []
   Keywords : Cell biology; Diabetes; Pregnancy; PKC; Apoptosis; Rat; Embryopathy; Vitamin E; Folic acid; CHC; NAC; Cellbiologi;

   Abstract : Maternal diabetes is associated with increased risk of growth disturbances and congenital malformations. The malformations rate in the offspring of diabetic mothers is 2-3 fold higher compared to infants of nondiabetic mothers. READ MORE