Search for dissertations about: "p53 gene family"

Showing result 1 - 5 of 27 swedish dissertations containing the words p53 gene family.

  2. 1. On the function of the interferon-inducible p53 target gene TRIM22

    Author : Jessica Petersson; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TRIM22; Staf50; p53; IFN; translation; proliferation; cell death;

    Abstract : The interferon-inducible p53-target gene TRIM22 (Staf50) is a member of the TRIM (TRIpartite Motif) family. The TRIM family is a family of RING (Really Interesting New Gene) proteins, defined through a tripartite motif, containing a RING-domain, one or two B-boxes and a Coiled-coil-domain. READ MORE

  4. 2. Pharmacological targeting of mutant p53 family members

    Author : Nina Rökaeus; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor suppressor p53 serves as a guardian of the genome and functions mainly as a transcription factor. In response to various stress signals p53 binds to specific DNA sequence motifs and regulates transcription of a large group of target genes involved in cellular processes such as cell cycle arrest, senescence and apoptosis. READ MORE

  5. 3. Transcriptional Regulation of the Platelet-Derived Growth Factor beta-receptor

    Author : Anders Hackzell; Göteborgs universitet; []
    Keywords : PDGF; cell cycle; p73; p53; SV40; NF-Y; Sp1; Myc;

    Abstract : The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses such as differentiation and cell movement. READ MORE

  6. 4. Molecular characterization of FOX factors and Wnt signalling interplay in human cancers

    Author : Giulia Pizzolato; Stefan Koch; Åsa Keita; Boudewijn Burgering; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; FOX proteins; Wnt signalling; p53; Tumour biology; Transcription factors; Proteine FOX; Via di segnalazione Wnt; p53; Biologia dei tumori; Fattori di trascrizione;

    Abstract : Wnt/β-catenin signalling, also referred to as canonical Wnt signalling, is a critical regulator of tissue homeostasis and of the differentiation of cells during development. The outcome of canonical Wnt pathway activity is defined by the regulation of target gene transcription, which ultimately determines cell identity and proliferation. READ MORE

  7. 5. Leucine-rich repeats and immunoglobulin-like domain (LRIG) proteins : possible prognostic markers in vulvar squamous cell carcinoma, endometrial carcinoma, and oropharymgeal squamous cell carcinoma

    Author : Husam Oda; David Lindquist; Eva Lundin; Ulrika Ottander; Kristina Stefansson; Kate Cuschieri; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vulvar squamous cell carcinoma; endometrial carcinoma; oropharyngeal squamous cell carcinoma; LRIG1-3; HPV; LMO7; HPV-driven; non-HPV-driven; prognosis; overall survival; disease-free survival; p53; Ki-67; CD8 TILs; CD44.; Pathology; patologi;

    Abstract : The human leucine-rich repeats and immunoglobulin-like domain (LRIG) gene family comprises three genes, LRIG1, LRIG2 and LRIG3, which encode the LRIG1, LRIG2 and LRIG3 proteins, respectively. Previous stidies have revealed the different prognostic roles of these proteins in different cancers, and it has been shown that LRIG1 functions as a tumour suppressor in certain cancers via its negative regulation of several receptor tyrosine kinases. READ MORE