Search for dissertations about: "paclitaxel mimetics"

Found 3 swedish dissertations containing the words paclitaxel mimetics.

2. 1. Design, synthesis and evaluation of spiro-bicyclo[2.2.2]octane derivatives as paclitaxel mimetics

   Author : Sophie Manner; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; asymmetric baker s yeast reduction; paclitaxel; spiro; bicyclo[2.2.2]octane; paclitaxel mimetics;

   Abstract : Nature contains an endless supply of natural products and has for long been a source of inspiration for the pharmaceutical industry. Many of the drugs currently in clinical use originate from natural products. READ MORE

4. 2. Synthesis of Spiro-bicyclo[2.2.2]Octane Derivatives Towards the Development of Paclitaxel Mimetics

   Author : Viveca Thornqvist; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Kemi; Organic chemistry; Organisk kemi; Chemistry; Natural science; paclitaxel; spiro; indium; Naturvetenskap; bicyclo[2.2.2]octane; allylation; paclitaxel mimetic;

   Abstract : Many of the drugs that are developed in the pharmaceutical industry have their origin in natural products. Paclitaxel, the active substance of the medicine Taxol, was found in the bark of the Pacific yew tree (Taxus brevifolia). READ MORE

5. 3. Roles of protein kinase C in cell death and breast cancer

   Author : Louise Cornmark; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; protein kinase C; apoptosis; cell death; Smac; Smac mimetics; IAP; stanniocalcin-1;

   Abstract : Aberrant protein kinase C (PKC) activity and expression is implicated in different malignancies. To study the role of different PKC isoforms in breast cancer the expression of PCKα, δ and ε was evaluated in breast cancer tumors. In addition the effect of siRNA-mediated knockdown of the isoforms was studied in a global gene expression analysis. READ MORE