Search for dissertations about: "patch-clamp"

Showing result 1 - 5 of 76 swedish dissertations containing the word patch-clamp.

  1. 1. Patch clamp and calcium studies on human colonic mucosal cells

    University dissertation from Stockholm : Karolinska Institutet, Department of Physiology and Pharmacology

    Author : Peter Sand; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human; colon crypt; HT29; K channel; Ca oscillations; volume regulation; patch clamp;

    Abstract : Background: The main function of the large intestine is to fine-tune electrolyte and water balance. This is achieved through the consorted action of ion channels, transporters and pumps. Failures of this system can lead to diarrhoea. READ MORE

  2. 2. Patch-clamp studies of the GABAA receptor using microfluidic methods

    University dissertation from Stockholm : Karolinska Institutet, Department of Physiology and Pharmacology

    Author : Maria Millingen; Chalmers tekniska högskola.; Chalmers University of Technology.; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biologi; Biology; Kemi; Chemistry; Bioteknik; Bioengineering; ion channel; microfluidics; GABAA receptor;

    Abstract : Ion channels are membrane proteins that passively transport ions. When activated, conformational changes within the protein lead to opening of a channel pore, and the flow of ions causes a change in the membrane potential. This is the fundamental process behind the generation and transduction of nerve impulses. READ MORE

  3. 3. Methods for elucidating membrane protein structure and function

    University dissertation from Chalmers University of Technology

    Author : Carolina L. Trkulja; Chalmers tekniska högskola.; Chalmers University of Technology.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Membrane proteins; ion channels; antibodies; TRPV1; patch clamp; fluorescence; limited proteolysis; proteomics; mass spectrometry; cholesterol.;

    Abstract : Elucidation of the structure-function relationship of membrane proteins increases our understanding of many biological processes, both physiological and pathological. However, membrane proteins have been notoriously difficult to study, having part of their structure embedded into the lipid cell membrane. READ MORE

  4. 4. On methods for probing structure and function of membrane proteins

    University dissertation from Chalmers University of Technology

    Author : Erik T. Jansson; Chalmers tekniska högskola.; Chalmers University of Technology.; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Membrane proteins; TRPV1; patch-clamp; fluorescence; cholesterol; microfluidic superfusion; proteoliposomes; proteomics; limited proteolysis; mass spectrometry.;

    Abstract : The determination of structure–function relationships in membrane proteins plays a key role for the understanding of molecular mechanisms in biological systems, and may provide information on how these systems can be modulated by pharmaceuticals. The aim of the work described herein was to develop methods for studying structure and function of membrane proteins, ideally in combination. READ MORE

  5. 5. Synaptic Integration of Hippocampal Neurons Generated in the Adult Brain: Influence of a Pathological Environment

    University dissertation from Neurology, Lund

    Author : Katherine Jakubs; Lunds universitet.; Lund University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurofysiologi; Neurologi; synaptic plasticity; GABA; glutamate; GFP; Neurology; neuropsychology; neurophysiology; hippocampus; dentate gyrus; neurogenesis; LPS; inflammation; epilepsy; SE; patch-clamp;

    Abstract : Popular Abstract in Swedish Tidigare trodde man att den vuxna hjärnan inte hade någon förmåga att nybilda nervceller. Detta skulle innebära att nervceller aldrig blev ersatta om de skadades eller dog. Nu vet man däremot att den vuxna hjärnan fortfarande producerar nya nervceller från särskilda moderceller, s.k. READ MORE