Search for dissertations about: "patogenes"

Showing result 1 - 5 of 25 swedish dissertations containing the word patogenes.

2. 1. TRANSMISSION AND PATHOGENESIS OF HANTAVIRUS

   Author : Lisa Pettersson; Magnus Evander; Clas Ahlm; Annika Allard; Tatjana Avšič - Županc; Umeå universitet; []
   Keywords : Puumala virus; Hantavirus; human-to-human transmission; saliva; nephropathia epidemica; NE; IgA; IgG; IgM; neutrophils; neutrophil; viremia; treatment; climate; snow cover; temperature.; medicinsk virologi; Medical Virology;

   Abstract : Hantaviruses are the causative agents of hemorrhagic fever with renal syndrome (HFRS) in Eurasia, and of hantavirus cardiopulmonary syndrome (HCPS) in the Americas. Transmission to humans usually occurs by inhalation of aerosolized virus-contaminated rodent excreta. READ MORE

4. 2. Host-pathogen interactions during tick-borne flavivirus infection : pathogenesis, tropism and tools

   Author : Ebba Rosendal; Anna K. Överby Wernstedt; Emma Nilsson; Jonathan D. Gilthorpe; Sonja M. Best; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tick-borne encephalitis virus; Langat virus; pathogenesis; type I interferons; central nervous system; neuroinflammation; structural proteins; Infectious Diseases; infektionssjukdomar; mikrobiologi; Microbiology;

   Abstract : Tick-borne encephalitis virus (TBEV) is a neurotropic member of the genus Flavivirus. It may transmit to humans through the bite of an infected tick or consumption of unpasteurized dairyproducts, and causes tick-borne encephalitis (TBE). TBE constitutes a significant health burden in Eurasia, with more than 10,000 cases reported every year. READ MORE

5. 3. The hematopoietic transcription factor RUNX1 : a structural view

   Author : Stefan Bäckström; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; RUNX1; Runt domain; CBFβ; transcription factor; leukaemia; protein crystallography; anomalous diffraction; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; molekylärbiologi; Molecular Biology;

   Abstract : The malfunction of the transcriptional regulator RUNX1 is the major cause of several variants of acute human leukemias and its normal function is to regulate the development of the blood system in concert with other transcriptional co-regulators. RUNX1 belongs to a conserved family of heterodimeric transcription factors that share a conserved DNA binding domain, the Runt domain (RD), named after the first member of this group – Runt - found in Drosophila melanogaster. READ MORE

6. 4. X-ray characterization of PaPheOH, a bacterial phenylalanine hydroxylase

   Author : Fredrik Ekström; Uwe H. Sauer; Edward Hough; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; PaPheOH; PheOH; PAH; phhA; phenylalanine hydroxylase; protein crystallography; a-actinin; microcrystal; ABD; CH-domain; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

   Abstract : Many human diseases are associated with the malfunction of enzymes in the aromatic amino acid hydroxylase family, e.g. phenylketonuria (PKU), hyperphenylalaninemia (HPA), schizophrenia and Parkinson's disease. READ MORE

7. 5. Transthyretin from a structural perspective

   Author : Andreas Hörnberg; Elisabeth Sauer-Eriksson; Hugo Monaco; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; X-ray crystallography; amyloidosis; structural comparison; anomalous diffraction; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : Conformational changes in human proteins can induce several types of diseases. The nature of the conformational changes is largely unknown, but some lead to amyloid fibril formation. Amyloid fibrils accumulate in the extra-cellular space of tissues resulting in disruption of organ function. READ MORE