Search for dissertations about: "perfusion technology"
Showing result 1 - 5 of 59 swedish dissertations containing the words perfusion technology.
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1. Tools for the development of intensified perfusion processes for mammalian cell culture
Abstract : Recombinant protein therapeutics have become an indispensable part of modern medicine to treat a wide variety of diseases. Their manufacture is mostly based on mammalian cells with fed-batch production bioreactors and downstream batch purification unit operations. READ MORE
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2. On perfusion estimation using ultrasound
Abstract : This thesis has the main focus on ways to improve the blood perfusion estimate, as obtained from a continuous wave Doppler system. Earlier studies have shown large temporal variations in the detected perfusion estimate, due to speckle. READ MORE
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3. Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures
Abstract : Chinese hamster ovary (CHO) cells are the most popular expression system for the production of biopharmaceuticals. More than 80% of the approved monoclonal antibodies (mAbs) or immunoglobulin G (IgG) are produced with these cells. Glycosylation is a usual post- translational modification important for therapeutic mAbs. READ MORE
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4. High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells
Abstract : Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of biopharmaceuticals, not only for labile drug protein but also for stable proteins such as monoclonal antibodies (mAbs). Perfusion mode can advantageously offer a stable cell environment, long-term production with high productivity and consistent product quality. READ MORE
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5. Micro-scale Platforms for Investigations of Biological Structures
Abstract : This thesis describes the development of innovative micro-scale platforms as a means to address the current challenges within the field of cell biology, and to provide an interface between miniaturized analytical technology and experimental systems for the life sciences. The work includes an analytical platform for rapid assessment of the viability of adherent single cells; a surface patterning strategy for investigations of cell-to-cell communication via protrusions; a versatile microfluidic probe in SU-8 hard-polymer, and a microfabricated millimeter-wave measurement system for the identification and characterization of niosome (non-ionic surfactant vesicle) constituents, which is operated in a label-free, non-invasive manner. READ MORE