Search for dissertations about: "peripheral resistance"

Showing result 1 - 5 of 170 swedish dissertations containing the words peripheral resistance.

2. 1. Pharmacology and resistance mechanisms of nucleoside analogues and topoisomerase II interactive agents : studies on human leukemia cells with a focus on cross-resistance

   Author : Kourosh Lotfi; Rolf Larsson; Linköpings universitet; []
   Keywords : Nucleoside analogue; cross-resistance; multidrug resistance; deoxycytidine kinase; leukemia; anthracyclines; P-glycoprotein; MEDICINE; MEDICIN;

   Abstract : The purpose of this thesis was to elucidate mechanisms of action and resistance of clinically relevant nucleoside analogues and topoisomerase interactive agents in human leukemia cell lines and leukernia cells isolated from peripheral blood of leukemia patients. Interactions and cross-resistance patterns of these different cytotoxic drug families were also studied since these drugs are usually administrated in combination in the clinic. READ MORE

4. 2. Fat cell insulin resistance : an experimental study focusing on molecular mechanisms in type 2 diabetes

   Author : Frida Renström; Jan Eriksson; Anna Krook; Umeå universitet; []
   Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; adipocyte; insulin signaling; insulin; glucose; IRS-1; glucose uptake; insulin resistance; typ 2 diabetes; serum; Medicine; Medicin;

   Abstract : The aim of the present thesis was to further increase our understanding of mechanisms contributing to and maintaining cellular insulin resistance in type 2 diabetes (T2D). For this reason, the effects of high glucose and insulin levels on glucose transport capacity and insulin signaling, with emphasis on insulin receptor substrate 1 (IRS-1) were assessed in fat cells. READ MORE

5. 3. Insulin resistance and cardiovascular function - Observational, translational and interventional studies

   Author : Helena Utkovic Westergren; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin resistance; microvascular function; peripheral vascular function; coronary flow reserve; prognosis; myocardial perfusion scintigram; animal model;

   Abstract : Background: Microvascular disease is now recognized as an important driver for cardiovascular mortality and morbidity. Diabetic patients are known to suffer from this condition, leading to e.g. coronary ischemia as well as kidney dysfunction. READ MORE

6. 4. Glucose and lipid metabolism in insulin resistance : an experimental study in fat cells

   Author : Jonas Burén; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; adipocyte; insulin resistance; type 2 diabetes; insulin signalling; glucose uptake; insulin; glucose; dexamethasone; insulin receptor substrate; protein kinase B; GLUT4; lipoprotein lipase; Folkhälsomedicin; Public health medicine research areas; Folkhälsomedicinska forskningsområden; medicin; Medicine;

   Abstract : Type 2 diabetes is usually caused by a combination of pancreatic β-cell failure and insulin resistance in target tissues like liver, muscle and fat. Insulin resistance is characterised by an impaired effect of insulin to reduce hepatic glucose production and to promote glucose uptake in peripheral tissues. READ MORE

7. 5. Arterial Thrombosis in Factor V Leiden or Activated Protein C Resistance. Clinical and Experimental Studies

   Author : Ellis Sampram; Malmö Klinisk koagulationsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Activated protein c resistance; Factor V Leiden mutation; thrombophilia; hypercoagulable state; Factor V Leiden mice; arterial thrombosis; venous thromboembolism; peripheral vascular reconstructions; peripheral vascular reconstruction occlusion;

   Abstract : Abstract The last two decades has seen an avalanche of studies establishing Activated protein C (APC) resistance due to Factor V Leiden mutation as the most prevalent genetic risk factor, yet known, for venous thromboembolism. This has been documented in 20-60% of patients with deep vein thrombosis (DVT). READ MORE