Search for dissertations about: "pharmacokinetics pharmacodynamics"

Showing result 1 - 5 of 94 swedish dissertations containing the words pharmacokinetics pharmacodynamics.

  2. 1. Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites

    Author : Marie V Magnusson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; Pentoxifylline; metabolites; pharmacodynamics;

    Abstract : Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). READ MORE

  4. 2. Pharmacokinetics and pharmacodynamics of the psychedelic compound DMT

    Author : Emma Eckernäs; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; N; N-dimethyltryptamine; psychedelic; nonlinear mixed effects modeling; pharmacokinetics; pharmacodynamics;

    Abstract : N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being investigated as a treatment option in depression. It is also being used as a research tool in research aiming to investigate the neurobiology of the human consciousness using brain imaging techniques. READ MORE

  5. 3. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy

    Author : Sofia Friberg Hietala; Göteborgs universitet; []
    Keywords : pharmacokinetics; pharmacodynamics; antimalarials; artemisinins;

    Abstract : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. READ MORE

  6. 4. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

    Author : Mats O. Magnusson; Rikard Sandström; Mats Karlsson; Ulf Bredberg; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

    Abstract : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. READ MORE

  7. 5. Mechanistic Based Pharmacokinetic-Pharmacodynamics models for Drug Interactions and Disease Population Predictions

    Author : Luna Prieto Garcia; Erik Sjögren; Aleksandra Galetin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiologically-Based Pharmacokinetics; Pharmacokinetics; Pharmacodynamics; Disease Modelling; Drug Interactions; Statins; Mechanistic Modelling; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : Therapeutic dose of a medication refers to the quantity of a drug required to produce a pharmacological effect without causing unacceptable adverse events. Dose selection in the clinical setting is not straight forward due to various factors, including specific patient factors such as age, sex, weight, genetic variants and renal/hepatic function, as well as external factors such as food and co-medication, all of which can influence the efficacy and safety of a drug. READ MORE